7NP1

Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-360

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Spike protein S1	polymer	232	26099.4	4	UniProt (P0DTC2) Pfam (PF09408) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
2	H, I, J, K	Immunoglobulin gamma-1 heavy chain	polymer	224	23397.2	4		Homo sapiens
3	L, M, N, O	Immunoblobulin light chain	polymer	217	23759.3	4		Homo sapiens (Human)
4	E, F	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	2	In PDB GlyTouCan (G86851RC)
5	B, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6		water	water		18.0	71	Chemie (HOH)

Sequence modifications

A, B, C, D: 319 - 539 (UniProt: P0DTC2)

PDB	External Database	Details
-	His 519	deletion
-	Ala 520	deletion
Ala 540	-	expression tag
Ala 541	-	expression tag
Ala 542	-	expression tag
Gly 543	-	expression tag
Ser 544	-	expression tag
His 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	293023.5
Branched	Number of molecules	2
	Total formula weight	734.7
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	294200.6

*Water molecules are not included.