7NNS
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound Momelotinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Activin receptor type I | polymer | 301 | 34537.6 | 1 | UniProt (Q04771) Pfam (PF00069) | Homo sapiens | |
| 2 | B, C, D, E, F... (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 3 | H (B) | Momelotinib | non-polymer | 414.5 | 1 | Chemie (C87) | |||
| 4 | I, J, K, L, M... (B) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 5 | P (B) | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
B: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
| Asp 207 | Gln 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34537.6 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1459.3 | |
| All* | Total formula weight | 35996.9 |
