7NL6
Crystal Structure of DC-SIGN in complex with a triazole-based glycomimetic ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DC-SIGN, CRD domain | polymer | 176 | 20049.1 | 1 | UniProt (Q9NNX6) Pfam (PF00059) | Homo sapiens (Human) | C-type lectin domain family 4 member L,Dendritic cell-specific ICAM-3-grabbing non-integrin 1,DC-SIGN,DC-SIGN1, CD209 antigen |
| 2 | B, C, D (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 3 | E (A) | Methyl 2-deoxy-2-(4-(pyridine-3-yl))-1,2,3-triazol-1-yl)-alpha-D-mannopyranoside | non-polymer | 322.3 | 1 | Chemie (UH8) | |||
| 4 | F (A) | NITRATE ION | non-polymer | 62.0 | 1 | Chemie (NO3) | |||
| 5 | G (A) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A: 250 - 404 (UniProt: Q9NNX6)
| PDB | External Database | Details |
|---|---|---|
| Met 229 | - | initiating methionine |
| Gly 230 | - | expression tag |
| Ser 231 | - | expression tag |
| Ser 232 | - | expression tag |
| His 233 | - | expression tag |
| His 234 | - | expression tag |
| His 235 | - | expression tag |
| His 236 | - | expression tag |
| His 237 | - | expression tag |
| His 238 | - | expression tag |
| Ser 239 | - | expression tag |
| Ser 240 | - | expression tag |
| Gly 241 | - | expression tag |
| Leu 242 | - | expression tag |
| Val 243 | - | expression tag |
| Pro 244 | - | expression tag |
| Arg 245 | - | expression tag |
| Gly 246 | - | expression tag |
| Ser 247 | - | expression tag |
| His 248 | - | expression tag |
| Met 249 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 20049.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 504.6 | |
| All* | Total formula weight | 20553.7 |
