7NIW
Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab (posaconazole-bound, inward-open conformation)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphatidylcholine translocator ABCB4 | polymer | 1279 | 140833.4 | 1 | UniProt (P21439) Pfam (PF00664) Pfam (PF00005) In PDB | Homo sapiens (human) | ATP-binding cassette sub-family B member 4,Multidrug resistance protein 3,P-glycoprotein 3 |
| 2 | B | 4B1 Fab-fragment light chain | polymer | 215 | 23347.0 | 1 | Homo sapiens | ||
| 3 | C | 4B1 Fab-fragment heavy chain | polymer | 241 | 25754.6 | 1 | Homo sapiens | ||
| 4 | A | CHOLESTEROL | non-polymer | 386.7 | 6 | Chemie (CLR) | |||
| 5 | A | POSACONAZOLE | non-polymer | 700.8 | 1 | Chemie (X2N) | |||
| 6 | A | 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 782.1 | 1 | Chemie (DLP) |
Sequence modifications
A: 1 - 1279 (UniProt: P21439)
| PDB | External Database | Details |
|---|---|---|
| Gln 558 | Glu 558 | engineered mutation |
| Gln 1200 | Glu 1200 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 189934.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3802.8 | |
| All* | Total formula weight | 193737.7 |
