7NIW
Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab (posaconazole-bound, inward-open conformation)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005548 | molecular_function | phospholipid transporter activity |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006869 | biological_process | lipid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030136 | cellular_component | clathrin-coated vesicle |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0032376 | biological_process | positive regulation of cholesterol transport |
| A | 0032782 | biological_process | bile acid secretion |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0045121 | cellular_component | membrane raft |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0046581 | cellular_component | intercellular canaliculus |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0055088 | biological_process | lipid homeostasis |
| A | 0061092 | biological_process | positive regulation of phospholipid translocation |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0090554 | molecular_function | phosphatidylcholine floppase activity |
| A | 0099038 | molecular_function | ceramide floppase activity |
| A | 0099040 | biological_process | ceramide translocation |
| A | 0140326 | molecular_function | ATPase-coupled intramembrane lipid transporter activity |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| A | 1901557 | biological_process | response to fenofibrate |
| A | 1903413 | biological_process | cellular response to bile acid |
| A | 2001140 | biological_process | positive regulation of phospholipid transport |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL |
| Chain | Residue | Details |
| A | LEU533-LEU547 | |
| A | LEU1175-LEU1189 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| B | TYR193-HIS199 | |
| C | TYR214-HIS220 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 623 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| A | MET1-ASP50 | |
| A | LEU140-ILE188 | |
| A | SER239-SER296 | |
| A | ASP355-PHE711 | |
| A | GLY777-ARG831 | |
| A | GLU874-LYS933 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 247 |
| Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | TRP51-LEU73 | |
| A | TRP854-VAL873 | |
| A | ALA934-PHE956 | |
| A | VAL973-ALA994 | |
| A | TYR119-THR139 | |
| A | GLY189-PHE210 | |
| A | LEU218-LEU238 | |
| A | ALA297-TYR318 | |
| A | ALA333-ILE354 | |
| A | VAL712-PHE732 | |
| A | LEU756-PHE776 | |
| A | LEU832-TYR852 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 101 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | MET74-TYR118 | |
| A | ILE211-THR217 | |
| A | GLY319-ASN332 | |
| A | SER733-SER755 | |
| A | GLY853 | |
| A | ARG957-ASP972 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31873305, ECO:0007744|PDB:6S7P |
| Chain | Residue | Details |
| A | ARG406 | |
| A | GLN477 | |
| A | GLY536 | |
| A | ARG1046 | |
| A | CYS1124 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0000269|PubMed:31873305, ECO:0007744|PDB:6S7P |
| Chain | Residue | Details |
| A | GLY432 | |
| A | SER1071 | |
| A | ALA1184 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P21440 |
| Chain | Residue | Details |
| A | SER27 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:24723470 |
| Chain | Residue | Details |
| A | THR34 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN91 | |
| A | ASN97 |
