7NGE
Crystal structure of L-Trp/Indoleamine 2,3-dioxygenagse 1 (hIDO1) complex with the JK-loop refined in the closed conformation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Indoleamine 2,3-dioxygenase 1 | polymer | 405 | 45300.9 | 4 | UniProt (P14902) Pfam (PF01231) In PDB | Homo sapiens (Human) | IDO-1,Indoleamine-pyrrole 2,3-dioxygenase |
2 | C, A, B | TRYPTOPHAN | non-polymer | 204.2 | 4 | Chemie (TRP) | |||
3 | A, D | N'-Formylkynurenine | non-polymer | 236.2 | 2 | Chemie (NFK) | |||
4 | C, A, B, D | GLYCEROL | non-polymer | 92.1 | 33 | Chemie (GOL) | |||
5 | B, A, C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
6 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
7 | B, C | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
8 | C | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
9 | water | water | 18.0 | 668 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 15 - 403 (UniProt: P14902)
PDB | External Database | Details |
---|---|---|
Met -1 | - | initiating methionine |
Gly 0 | - | expression tag |
Ser 1 | - | expression tag |
Ser 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
His 5 | - | expression tag |
His 6 | - | expression tag |
His 7 | - | expression tag |
His 8 | - | expression tag |
Ser 9 | - | expression tag |
Ser 10 | - | expression tag |
Gly 11 | - | expression tag |
Ser 12 | - | expression tag |
Ala 13 | - | expression tag |
Ala 14 | - | expression tag |
Ala 116 | Lys 116 | engineered mutation |
Ala 117 | Lys 117 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 181203.6 | |
Non-Polymers* | Number of molecules | 48 |
Total formula weight | 7137.8 | |
All* | Total formula weight | 188341.3 |