Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7NGE

Crystal structure of L-Trp/Indoleamine 2,3-dioxygenagse 1 (hIDO1) complex with the JK-loop refined in the closed conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0002666	biological_process	positive regulation of T cell tolerance induction
A	0002678	biological_process	positive regulation of chronic inflammatory response
A	0002830	biological_process	positive regulation of type 2 immune response
A	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006569	biological_process	L-tryptophan catabolic process
A	0006954	biological_process	inflammatory response
A	0007565	biological_process	female pregnancy
A	0009055	molecular_function	electron transfer activity
A	0016491	molecular_function	oxidoreductase activity
A	0019441	biological_process	L-tryptophan catabolic process to kynurenine
A	0019805	biological_process	quinolinate biosynthetic process
A	0020037	molecular_function	heme binding
A	0030485	cellular_component	smooth muscle contractile fiber
A	0032421	cellular_component	stereocilium bundle
A	0032496	biological_process	response to lipopolysaccharide
A	0032693	biological_process	negative regulation of interleukin-10 production
A	0032735	biological_process	positive regulation of interleukin-12 production
A	0033555	biological_process	multicellular organismal response to stress
A	0033754	molecular_function	indoleamine 2,3-dioxygenase activity
A	0034276	biological_process	kynurenic acid biosynthetic process
A	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
A	0036269	biological_process	swimming behavior
A	0042098	biological_process	T cell proliferation
A	0042130	biological_process	negative regulation of T cell proliferation
A	0043065	biological_process	positive regulation of apoptotic process
A	0046006	biological_process	regulation of activated T cell proliferation
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0070233	biological_process	negative regulation of T cell apoptotic process
A	0070234	biological_process	positive regulation of T cell apoptotic process
B	0002376	biological_process	immune system process
B	0002666	biological_process	positive regulation of T cell tolerance induction
B	0002678	biological_process	positive regulation of chronic inflammatory response
B	0002830	biological_process	positive regulation of type 2 immune response
B	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006569	biological_process	L-tryptophan catabolic process
B	0006954	biological_process	inflammatory response
B	0007565	biological_process	female pregnancy
B	0009055	molecular_function	electron transfer activity
B	0016491	molecular_function	oxidoreductase activity
B	0019441	biological_process	L-tryptophan catabolic process to kynurenine
B	0019805	biological_process	quinolinate biosynthetic process
B	0020037	molecular_function	heme binding
B	0030485	cellular_component	smooth muscle contractile fiber
B	0032421	cellular_component	stereocilium bundle
B	0032496	biological_process	response to lipopolysaccharide
B	0032693	biological_process	negative regulation of interleukin-10 production
B	0032735	biological_process	positive regulation of interleukin-12 production
B	0033555	biological_process	multicellular organismal response to stress
B	0033754	molecular_function	indoleamine 2,3-dioxygenase activity
B	0034276	biological_process	kynurenic acid biosynthetic process
B	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
B	0036269	biological_process	swimming behavior
B	0042098	biological_process	T cell proliferation
B	0042130	biological_process	negative regulation of T cell proliferation
B	0043065	biological_process	positive regulation of apoptotic process
B	0046006	biological_process	regulation of activated T cell proliferation
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
B	0070233	biological_process	negative regulation of T cell apoptotic process
B	0070234	biological_process	positive regulation of T cell apoptotic process
C	0002376	biological_process	immune system process
C	0002666	biological_process	positive regulation of T cell tolerance induction
C	0002678	biological_process	positive regulation of chronic inflammatory response
C	0002830	biological_process	positive regulation of type 2 immune response
C	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006569	biological_process	L-tryptophan catabolic process
C	0006954	biological_process	inflammatory response
C	0007565	biological_process	female pregnancy
C	0009055	molecular_function	electron transfer activity
C	0016491	molecular_function	oxidoreductase activity
C	0019441	biological_process	L-tryptophan catabolic process to kynurenine
C	0019805	biological_process	quinolinate biosynthetic process
C	0020037	molecular_function	heme binding
C	0030485	cellular_component	smooth muscle contractile fiber
C	0032421	cellular_component	stereocilium bundle
C	0032496	biological_process	response to lipopolysaccharide
C	0032693	biological_process	negative regulation of interleukin-10 production
C	0032735	biological_process	positive regulation of interleukin-12 production
C	0033555	biological_process	multicellular organismal response to stress
C	0033754	molecular_function	indoleamine 2,3-dioxygenase activity
C	0034276	biological_process	kynurenic acid biosynthetic process
C	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
C	0036269	biological_process	swimming behavior
C	0042098	biological_process	T cell proliferation
C	0042130	biological_process	negative regulation of T cell proliferation
C	0043065	biological_process	positive regulation of apoptotic process
C	0046006	biological_process	regulation of activated T cell proliferation
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	0070233	biological_process	negative regulation of T cell apoptotic process
C	0070234	biological_process	positive regulation of T cell apoptotic process
D	0002376	biological_process	immune system process
D	0002666	biological_process	positive regulation of T cell tolerance induction
D	0002678	biological_process	positive regulation of chronic inflammatory response
D	0002830	biological_process	positive regulation of type 2 immune response
D	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006569	biological_process	L-tryptophan catabolic process
D	0006954	biological_process	inflammatory response
D	0007565	biological_process	female pregnancy
D	0009055	molecular_function	electron transfer activity
D	0016491	molecular_function	oxidoreductase activity
D	0019441	biological_process	L-tryptophan catabolic process to kynurenine
D	0019805	biological_process	quinolinate biosynthetic process
D	0020037	molecular_function	heme binding
D	0030485	cellular_component	smooth muscle contractile fiber
D	0032421	cellular_component	stereocilium bundle
D	0032496	biological_process	response to lipopolysaccharide
D	0032693	biological_process	negative regulation of interleukin-10 production
D	0032735	biological_process	positive regulation of interleukin-12 production
D	0033555	biological_process	multicellular organismal response to stress
D	0033754	molecular_function	indoleamine 2,3-dioxygenase activity
D	0034276	biological_process	kynurenic acid biosynthetic process
D	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
D	0036269	biological_process	swimming behavior
D	0042098	biological_process	T cell proliferation
D	0042130	biological_process	negative regulation of T cell proliferation
D	0043065	biological_process	positive regulation of apoptotic process
D	0046006	biological_process	regulation of activated T cell proliferation
D	0046872	molecular_function	metal ion binding
D	0051213	molecular_function	dioxygenase activity
D	0070233	biological_process	negative regulation of T cell apoptotic process
D	0070234	biological_process	positive regulation of T cell apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS00876
Number of Residues	11
Details	IDO_1 Indoleamine 2,3-dioxygenase signature 1. GGSAGQSSvfQ

Chain	Residue	Details
A	GLY261-GLN271

site_id	PS00877
Number of Residues	14
Details	IDO_2 Indoleamine 2,3-dioxygenase signature 2. FLQDMrrYMppaHR

Chain	Residue	Details
A	PHE291-ARG304

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	13
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"proximal binding residue","evidences":[{"source":"PubMed","id":"16477023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25313323","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D0U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PK6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)