7NDO

ER-PRS*(-) (L536S, L372R) in complex with raloxifene

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Estrogen receptor	polymer	247	28474.3	2	UniProt (P03372) Pfam (PF00104) In PDB	Homo sapiens (Human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2	A, B	RALOXIFENE	non-polymer		473.6	2	Chemie (RAL)
3	A, B	1,2-ETHANEDIOL	non-polymer		62.1	8	Chemie (EDO)
4	A	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
5		water	water		18.0	289	Chemie (HOH)

Sequence modifications

A, B: 304 - 548 (UniProt: P03372)

PDB	External Database	Details
Ser 302	-	expression tag
Met 303	-	expression tag
Ile 315	Met 315	engineered mutation
Ile 316	Val 316	engineered mutation
Glu 321	Asp 321	engineered mutation
Ser 334	Thr 334	engineered mutation
Tyr 341	Ser 341	engineered mutation
Lys 363	Arg 363	engineered mutation
Ser 371	Thr 371	engineered mutation
Arg 372	Leu 372	engineered mutation
Ser 381	Cys 381	engineered mutation
Asp 397	Glu 397	engineered mutation
Asp 407	Asn 407	engineered mutation
Glu 413	Asn 413	engineered mutation
Ser 417	Cys 417	engineered mutation
Glu 433	Ser 433	engineered mutation
Glu 437	Met 437	engineered mutation
Lys 439	Asn 439	engineered mutation
Arg 442	Gly 442	engineered mutation
Ala 450	Ser 450	engineered mutation
Asn 471	Glu 471	engineered mutation
Glu 473	Asp 473	engineered mutation
Lys 474	His 474	engineered mutation
Met 478	Val 478	engineered mutation
Ala 485	Thr 485	engineered mutation
Trp 488	His 488	engineered mutation
Tyr 489	Leu 489	engineered mutation
Ser 493	Ala 493	engineered mutation
Ser 496	Thr 496	engineered mutation
Ser 530	Cys 530	engineered mutation
Ser 536	Leu 536	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56948.7
Non-Polymers*	Number of molecules	13
	Total formula weight	1550.1
All*	Total formula weight	58498.8

*Water molecules are not included.