7NDO
ER-PRS*(-) (L536S, L372R) in complex with raloxifene
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue RAL A 601 |
| Chain | Residue |
| A | LEU346 |
| A | ASN532 |
| A | PRO535 |
| A | HOH761 |
| A | ALA350 |
| A | ASP351 |
| A | GLU353 |
| A | LEU354 |
| A | LEU387 |
| A | ARG394 |
| A | ILE424 |
| A | HIS524 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| A | ASP407 |
| A | LEU409 |
| A | GLN414 |
| A | HOH714 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 603 |
| Chain | Residue |
| A | ARG372 |
| A | EDO604 |
| A | HOH750 |
| A | HOH770 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 604 |
| Chain | Residue |
| A | LYS362 |
| A | ARG372 |
| A | LEU544 |
| A | EDO603 |
| A | HOH725 |
| B | VAL368 |
| B | ASP369 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 605 |
| Chain | Residue |
| A | TYR328 |
| A | ARG352 |
| A | HOH789 |
| B | HIS356 |
| B | HOH778 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 606 |
| Chain | Residue |
| A | HIS356 |
| A | HOH755 |
| A | HOH789 |
| B | TYR328 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 607 |
| Chain | Residue |
| A | GLU444 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue RAL B 601 |
| Chain | Residue |
| B | LEU346 |
| B | THR347 |
| B | ASP351 |
| B | GLU353 |
| B | LEU387 |
| B | ARG394 |
| B | ILE424 |
| B | HIS524 |
| B | VAL533 |
| B | PRO535 |
| B | HOH704 |
| B | HOH748 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | binding site for residue EDO B 602 |
| Chain | Residue |
| B | ASP313 |
| B | ILE316 |
| B | SER317 |
| B | LEU320 |
| B | GLU339 |
| B | TRP488 |
| B | LYS492 |
| B | EDO604 |
| B | HOH702 |
| B | HOH705 |
| B | HOH735 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 603 |
| Chain | Residue |
| B | GLU323 |
| B | ARG394 |
| B | PHE445 |
| B | LYS449 |
| B | HOH718 |
| B | HOH743 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 604 |
| Chain | Residue |
| B | SER317 |
| B | LEU320 |
| B | GLU321 |
| B | EDO602 |
| B | HOH705 |
| B | HOH706 |
| B | HOH715 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 605 |
| Chain | Residue |
| B | ASP407 |
| B | LEU408 |
| B | LEU409 |
| B | GLN414 |
| B | THR465 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 606 |
| Chain | Residue |
| B | GLN441 |
| B | GLU444 |
| B | TYR489 |
| B | SER493 |
| B | LEU495 |
| B | ARG503 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
