7NBF

Crystal structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	AAA, BBB, CCC, DDD	Serine racemase	polymer	346	37455.9	4	UniProt (Q9GZT4) Pfam (PF00291) In PDB	Homo sapiens (Human)	D-serine ammonia-lyase,D-serine dehydratase,L-serine ammonia-lyase,L-serine dehydratase
2	AAA, DDD, BBB, CCC	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	4	Chemie (PLP)
3	CCC, AAA, BBB	GLYCEROL	non-polymer		92.1	9	Chemie (GOL)
4	DDD, AAA, BBB, CCC	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
5	DDD, AAA	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	AAA	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
7	CCC, DDD, AAA, BBB	2-[(methylsulfonyl)methyl]-1H-benzimidazole	non-polymer		210.3	4	Chemie (T6J)
8	DDD, AAA, BBB	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
9	CCC, DDD, BBB	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
10	CCC	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
11	CCC, DDD	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
12		water	water		18.0	920	Chemie (HOH)

Sequence modifications

AAA, BBB, CCC, DDD: 1 - 340 (UniProt: Q9GZT4)

PDB	External Database	Details
Asp 2	Cys 2	engineered mutation
Asp 6	Cys 6	engineered mutation
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	149823.5
Non-Polymers*	Number of molecules	38
	Total formula weight	3649.0
All*	Total formula weight	153472.5

*Water molecules are not included.