7NBF

Crystal structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (AAA, BBB, CCC, DDD)	Serine racemase	polymer	346	37455.9	4	UniProt (Q9GZT4) Pfam (PF00291)	Homo sapiens (Human)	D-serine ammonia-lyase,D-serine dehydratase,L-serine ammonia-lyase,L-serine dehydratase
2	E, GA, P, X (AAA, DDD, BBB, CCC)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	4	Chemie (PLP)
3	BA, EA, F, G, H... (CCC, AAA, BBB)	GLYCEROL	non-polymer		92.1	9	Chemie (GOL)
4	HA, I, N, S, T... (DDD, AAA, BBB, CCC)	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
5	IA, J (DDD, AAA)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	K (AAA)	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
7	AA, KA, M, U (CCC, DDD, AAA, BBB)	2-[(methylsulfonyl)methyl]-1H-benzimidazole	non-polymer		210.3	4	Chemie (T6J)
8	JA, O, OA, W (DDD, AAA, BBB)	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
9	CA, LA, MA, NA, V (CCC, DDD, BBB)	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
10	DA (CCC)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
11	FA, PA (CCC, DDD)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
12	QA, RA, SA, TA (AAA, BBB, CCC, DDD)	water	water		18.0	920	Chemie (HOH)

Sequence modifications

AAA, BBB, CCC, DDD: 1 - 340 (UniProt: Q9GZT4)

PDB	External Database	Details
Asp 2	Cys 2	engineered mutation
Asp 6	Cys 6	engineered mutation
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	149823.5
Non-Polymers*	Number of molecules	38
	Total formula weight	3649.0
All*	Total formula weight	153472.5

*Water molecules are not included.