7NBC

Crystal structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (AAA, BBB, CCC, DDD)	Serine racemase	polymer	346	37455.9	4	UniProt (Q9GZT4) Pfam (PF00291)	Homo sapiens (Human)	D-serine ammonia-lyase,D-serine dehydratase,L-serine ammonia-lyase,L-serine dehydratase
2	AA, E, IA, S (CCC, AAA, DDD, BBB)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	4	Chemie (PLP)		D-serine ammonia-lyase,D-serine dehydratase,L-serine ammonia-lyase,L-serine dehydratase
3	BA, F, G, HA, J... (CCC, AAA, BBB)	GLYCEROL	non-polymer		92.1	10	Chemie (GOL)
4	CA, H, JA, O, U... (CCC, AAA, DDD, BBB)	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
5	I, KA (AAA, DDD)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	FA, GA, K, L, MA... (CCC, AAA, DDD, BBB)	1,2-ETHANEDIOL	non-polymer		62.1	10	Chemie (EDO)
7	LA, P, Q, R (DDD, AAA)	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
8	DA (CCC)	2-(2-METHOXYETHOXY)ETHANOL	non-polymer		120.1	1	Chemie (PG0)
9	EA (CCC)	biphenyl-4-ylacetic acid	non-polymer		212.2	1	Chemie (BP4)
10	QA, RA, SA, TA (AAA, BBB, CCC, DDD)	water	water		18.0	867	Chemie (HOH)

Sequence modifications

AAA, BBB, CCC, DDD: 1 - 340 (UniProt: Q9GZT4)

PDB	External Database	Details
Asp 2	Cys 2	engineered mutation
Asp 6	Cys 6	engineered mutation
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	149823.5
Non-Polymers*	Number of molecules	38
	Total formula weight	3243.6
All*	Total formula weight	153067.1

*Water molecules are not included.