7NA7

Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	354	40429.1	1	UniProt (P63096) Pfam (PF00503) In PDB	Homo sapiens (Human)	Adenylate cyclase-inhibiting G alpha protein
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	340	37417.9	1	UniProt (P62873) Pfam (PF00400) In PDB	Homo sapiens (Human)	Transducin beta chain 1
3	G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7859.2	1	UniProt (P59768) Pfam (PF00631) In PDB	Homo sapiens (Human)	G gamma-I
4	N	Antibody fragment	polymer	246	26236.2	1		Mus musculus (Mouse)
5	R	Growth hormone secretagogue receptor type 1	polymer	366	41406.4	1	UniProt (Q92847) Pfam (PF00001) In PDB	Homo sapiens (Human)	GHS-R,GH-releasing peptide receptor,GHRP,Ghrelin receptor
6	L	Ghrelin-27	polymer	12	1471.7	1	UniProt (Q9UBU3) Pfam (PF04644) In PDB	Homo sapiens
7	R	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)

Sequence modifications

A: 1 - 354 (UniProt: P63096)

PDB	External Database	Details
Glu 328	Asp 328	conflict

B: 1 - 340 (UniProt: P62873)

G: 1 - 71 (UniProt: P59768)

PDB	External Database	Details
Gln 17	Glu 17	conflict
Gln 58	Glu 58	conflict

R: 1 - 366 (UniProt: Q92847)

PDB	External Database	Details
Lys 130	Thr 130	conflict
Gln 188	Asn 188	conflict

L: 1 - 12 (UniProt: Q9UBU3)

PDB	External Database	Details
1ic 3	Ser 26	engineered mutation

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.