7NA5

Structure of the H2DB-TCR ternary complex with HSF2 melanoma neoantigen

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	H-2 class I histocompatibility antigen, D-B alpha chain	polymer	281	32601.3	1	UniProt (P01899) Pfam (PF00129) Pfam (PF07654)	Mus musculus (Mouse)	H-2D(B)
2	B (B)	Beta-2-microglobulin	polymer	100	11879.4	1	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	C (C)	Heat shock factor protein 2	polymer	9	1106.3	1	UniProt (P38533)	Mus musculus	HSF 2,Heat shock transcription factor 2,HSTF 2
4	D (D)	47BE7 TCR alpha chain	polymer	191	21426.9	1		Mus musculus (Mouse)
5	E (E)	47BE7 TCR beta chain	polymer	263	29788.3	1		Mus musculus (Mouse)
6	F, G, H, I, J... (A, B, C, D, E)	GLYCEROL	non-polymer		92.1	13	Chemie (GOL)
7	L, Q, U, V (A, D, E)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
8	AA, W, X, Y, Z (E, A, B, C, D)	water	water		18.0	208	Chemie (HOH)

Sequence modifications

A: 1 - 280 (UniProt: P01899)

PDB	External Database	Details
Met 0	-	initiating methionine

B: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

C: 1 - 9 (UniProt: P38533)

PDB	External Database	Details
Asn 5	Lys 72	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	96802.2
Non-Polymers*	Number of molecules	17
	Total formula weight	1581.5
All*	Total formula weight	98383.7

*Water molecules are not included.