7N9C
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB95
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Spike glycoprotein | polymer | 1380 | 152312.8 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2 COVID-19 virus) | S glycoprotein,E2,Peplomer protein |
| 2 | D, E (D, E) | Nanobody NB95 | polymer | 155 | 17146.8 | 2 | Lama glama |
Sequence modifications
A, B, C: 93 - 1300 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Gly 3 | - | expression tag |
| Glu 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Leu 6 | - | expression tag |
| Arg 7 | - | expression tag |
| Ala 8 | - | expression tag |
| Ser 9 | - | expression tag |
| Pro 10 | - | expression tag |
| Arg 11 | - | expression tag |
| Arg 12 | - | expression tag |
| Arg 13 | - | expression tag |
| Pro 14 | - | expression tag |
| Leu 15 | - | expression tag |
| Leu 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Leu 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Pro 20 | - | expression tag |
| Arg 21 | - | expression tag |
| Gly 22 | - | expression tag |
| Cys 23 | - | expression tag |
| Pro 24 | - | expression tag |
| Arg 25 | - | expression tag |
| Gly 26 | - | expression tag |
| Asp 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Cys 29 | - | expression tag |
| Leu 30 | - | expression tag |
| Arg 31 | - | expression tag |
| Gly 32 | - | expression tag |
| Gly 33 | - | expression tag |
| Arg 34 | - | expression tag |
| Gly 35 | - | expression tag |
| Arg 36 | - | expression tag |
| Ala 37 | - | expression tag |
| Gly 38 | - | expression tag |
| Phe 39 | - | expression tag |
| Gly 40 | - | expression tag |
| Phe 41 | - | expression tag |
| Trp 42 | - | expression tag |
| Arg 43 | - | expression tag |
| Val 44 | - | expression tag |
| Thr 45 | - | expression tag |
| Gly 46 | - | expression tag |
| Gly 47 | - | expression tag |
| Ser 48 | - | expression tag |
| Ser 49 | - | expression tag |
| Ala 50 | - | expression tag |
| Ser 51 | - | expression tag |
| Ala 52 | - | expression tag |
| Asn 53 | - | expression tag |
| His 54 | - | expression tag |
| Val 55 | - | expression tag |
| His 56 | - | expression tag |
| Ala 57 | - | expression tag |
| Phe 58 | - | expression tag |
| Phe 59 | - | expression tag |
| Phe 60 | - | expression tag |
| Phe 61 | - | expression tag |
| Leu 62 | - | expression tag |
| Gln 63 | - | expression tag |
| Leu 64 | - | expression tag |
| Leu 65 | - | expression tag |
| Gly 66 | - | expression tag |
| Asn 67 | - | expression tag |
| Val 68 | - | expression tag |
| Leu 69 | - | expression tag |
| Val 70 | - | expression tag |
| Val 71 | - | expression tag |
| Val 72 | - | expression tag |
| Leu 73 | - | expression tag |
| Ser 74 | - | expression tag |
| His 75 | - | expression tag |
| His 76 | - | expression tag |
| Phe 77 | - | expression tag |
| Gly 78 | - | expression tag |
| Lys 79 | - | expression tag |
| Glu 80 | - | expression tag |
| Leu 81 | - | expression tag |
| Arg 82 | - | expression tag |
| Pro 83 | - | expression tag |
| Ser 84 | - | expression tag |
| Gln 85 | - | expression tag |
| Ala 86 | - | expression tag |
| Glu 87 | - | expression tag |
| Phe 88 | - | expression tag |
| Gly 89 | - | expression tag |
| Thr 90 | - | expression tag |
| Ala 91 | - | expression tag |
| Thr 92 | - | expression tag |
| Gly 774 | Arg 682 | engineered mutation |
| Ser 775 | Arg 683 | engineered mutation |
| Ser 777 | Arg 685 | engineered mutation |
| Pro 909 | Phe 817 | engineered mutation |
| Pro 984 | Ala 892 | engineered mutation |
| Pro 991 | Ala 899 | engineered mutation |
| Pro 1034 | Ala 942 | engineered mutation |
| Pro 1078 | Lys 986 | engineered mutation |
| Pro 1079 | Val 987 | engineered mutation |
| Gly 1301 | - | expression tag |
| Ser 1302 | - | expression tag |
| Gly 1303 | - | expression tag |
| Tyr 1304 | - | expression tag |
| Ile 1305 | - | expression tag |
| Pro 1306 | - | expression tag |
| Glu 1307 | - | expression tag |
| Ala 1308 | - | expression tag |
| Pro 1309 | - | expression tag |
| Arg 1310 | - | expression tag |
| Asp 1311 | - | expression tag |
| Gly 1312 | - | expression tag |
| Gln 1313 | - | expression tag |
| Ala 1314 | - | expression tag |
| Tyr 1315 | - | expression tag |
| Val 1316 | - | expression tag |
| Arg 1317 | - | expression tag |
| Lys 1318 | - | expression tag |
| Asp 1319 | - | expression tag |
| Gly 1320 | - | expression tag |
| Glu 1321 | - | expression tag |
| Trp 1322 | - | expression tag |
| Val 1323 | - | expression tag |
| Leu 1324 | - | expression tag |
| Leu 1325 | - | expression tag |
| Ser 1326 | - | expression tag |
| Thr 1327 | - | expression tag |
| Phe 1328 | - | expression tag |
| Leu 1329 | - | expression tag |
| Gly 1330 | - | expression tag |
| Arg 1331 | - | expression tag |
| Ser 1332 | - | expression tag |
| Leu 1333 | - | expression tag |
| Glu 1334 | - | expression tag |
| Val 1335 | - | expression tag |
| Leu 1336 | - | expression tag |
| Phe 1337 | - | expression tag |
| Gln 1338 | - | expression tag |
| Gly 1339 | - | expression tag |
| Pro 1340 | - | expression tag |
| Gly 1341 | - | expression tag |
| His 1342 | - | expression tag |
| His 1343 | - | expression tag |
| His 1344 | - | expression tag |
| His 1345 | - | expression tag |
| His 1346 | - | expression tag |
| His 1347 | - | expression tag |
| His 1348 | - | expression tag |
| His 1349 | - | expression tag |
| Ser 1350 | - | expression tag |
| Ala 1351 | - | expression tag |
| Trp 1352 | - | expression tag |
| Ser 1353 | - | expression tag |
| His 1354 | - | expression tag |
| Pro 1355 | - | expression tag |
| Gln 1356 | - | expression tag |
| Phe 1357 | - | expression tag |
| Glu 1358 | - | expression tag |
| Lys 1359 | - | expression tag |
| Gly 1360 | - | expression tag |
| Gly 1361 | - | expression tag |
| Gly 1362 | - | expression tag |
| Ser 1363 | - | expression tag |
| Gly 1364 | - | expression tag |
| Gly 1365 | - | expression tag |
| Gly 1366 | - | expression tag |
| Gly 1367 | - | expression tag |
| Ser 1368 | - | expression tag |
| Gly 1369 | - | expression tag |
| Gly 1370 | - | expression tag |
| Ser 1371 | - | expression tag |
| Ala 1372 | - | expression tag |
| Trp 1373 | - | expression tag |
| Ser 1374 | - | expression tag |
| His 1375 | - | expression tag |
| Pro 1376 | - | expression tag |
| Gln 1377 | - | expression tag |
| Phe 1378 | - | expression tag |
| Glu 1379 | - | expression tag |
| Lys 1380 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 491231.9 | |
| All* | Total formula weight | 491231.9 |
