7N81
Crystal Structure of PI5P4KIIBeta complex with CC260
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | polymer | 392 | 44800.8 | 2 | UniProt (P78356) Pfam (PF01504) | Homo sapiens (Human) | 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta,Diphosphoinositide kinase 2-beta,Phosphatidylinositol 5-phosphate 4-kinase type II beta,PI(5)P 4-kinase type II beta,PIP4KII-beta,PtdIns(5)P-4-kinase isoform 2-beta |
| 2 | C (B) | (7R)-8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-5-methyl-7,8-dihydropteridin-6(5H)-one | non-polymer | 490.4 | 1 | Chemie (HKP) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 138 | Chemie (HOH) |
Sequence modifications
A, B: 32 - 416 (UniProt: P78356)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | expression tag |
| Pro 26 | - | expression tag |
| Asn 27 | - | expression tag |
| Cys 28 | - | expression tag |
| Ala 29 | - | expression tag |
| Pro 30 | - | expression tag |
| Gly 31 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 89601.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 490.4 | |
| All* | Total formula weight | 90092.0 |
