7N81

Crystal Structure of PI5P4KIIBeta complex with CC260

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005776	cellular_component	autophagosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0007166	biological_process	cell surface receptor signaling pathway
A	0010506	biological_process	regulation of autophagy
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016308	molecular_function	1-phosphatidylinositol-4-phosphate 5-kinase activity
A	0016309	molecular_function	1-phosphatidylinositol-5-phosphate 4-kinase activity
A	0016740	molecular_function	transferase activity
A	0042803	molecular_function	protein homodimerization activity
A	0046488	biological_process	phosphatidylinositol metabolic process
A	0046627	biological_process	negative regulation of insulin receptor signaling pathway
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0052742	molecular_function	phosphatidylinositol kinase activity
A	0061909	biological_process	autophagosome-lysosome fusion
A	1902635	biological_process	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
A	2000786	biological_process	positive regulation of autophagosome assembly
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005776	cellular_component	autophagosome
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0007166	biological_process	cell surface receptor signaling pathway
B	0010506	biological_process	regulation of autophagy
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016308	molecular_function	1-phosphatidylinositol-4-phosphate 5-kinase activity
B	0016309	molecular_function	1-phosphatidylinositol-5-phosphate 4-kinase activity
B	0016740	molecular_function	transferase activity
B	0042803	molecular_function	protein homodimerization activity
B	0046488	biological_process	phosphatidylinositol metabolic process
B	0046627	biological_process	negative regulation of insulin receptor signaling pathway
B	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
B	0052742	molecular_function	phosphatidylinositol kinase activity
B	0061909	biological_process	autophagosome-lysosome fusion
B	1902635	biological_process	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
B	2000786	biological_process	positive regulation of autophagosome assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Region: {"description":"Required for interaction with PIP5K1A","evidences":[{"source":"UniProtKB","id":"Q8TBX8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26774281","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3X03","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26774281","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3X04","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P48426","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 662

Chain	Residue	Details
A	LYS150	electrostatic stabiliser
A	ASP278	proton shuttle (general acid/base)

---

site_id	MCSA2
Number of Residues	2
Details	M-CSA 662

Chain	Residue	Details
B	LYS150	electrostatic stabiliser
B	ASP278	proton shuttle (general acid/base)

---