7N7N
Crystal Structure of PI5P4KIIAlpha complex with Volasertib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | polymer | 377 | 43114.7 | 1 | UniProt (P48426) Pfam (PF01504) | Homo sapiens (Human) | 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha,Diphosphoinositide kinase 2-alpha,PIP5KIII,Phosphatidylinositol 5-Phosphate 4-Kinase,PI5P4Kalpha,Phosphatidylinositol 5-phosphate 4-kinase type II alpha,PI(5)P 4-kinase type II alpha,PIP4KII-alpha,PtdIns(4)P-5-kinase B isoform,PtdIns(4)P-5-kinase C isoform,PtdIns(5)P-4-kinase isoform 2-alpha |
| 2 | B (A) | N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide | non-polymer | 618.8 | 1 | Chemie (IBI) | |||
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F (A) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A: 33 - 405 (UniProt: P48426)
| PDB | External Database | Details |
|---|---|---|
| Gly 29 | - | expression tag |
| Ser 30 | - | expression tag |
| His 31 | - | expression tag |
| Met 32 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43114.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 907.0 | |
| All* | Total formula weight | 44021.7 |
