7N7N

Crystal Structure of PI5P4KIIAlpha complex with Volasertib

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001750	cellular_component	photoreceptor outer segment
A	0001917	cellular_component	photoreceptor inner segment
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0010506	biological_process	regulation of autophagy
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016308	molecular_function	1-phosphatidylinositol-4-phosphate 5-kinase activity
A	0016309	molecular_function	1-phosphatidylinositol-5-phosphate 4-kinase activity
A	0016740	molecular_function	transferase activity
A	0035855	biological_process	megakaryocyte development
A	0042803	molecular_function	protein homodimerization activity
A	0042995	cellular_component	cell projection
A	0046488	biological_process	phosphatidylinositol metabolic process
A	0046627	biological_process	negative regulation of insulin receptor signaling pathway
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0052742	molecular_function	phosphatidylinositol kinase activity
A	0061909	biological_process	autophagosome-lysosome fusion
A	0090119	biological_process	vesicle-mediated cholesterol transport
A	1902635	biological_process	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
A	2000786	biological_process	positive regulation of autophagosome assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Region: {"description":"Required for interaction with PIP5K1A","evidences":[{"source":"UniProtKB","id":"Q8TBX8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---