7N6R

Structure of nevanimibe bound human ACAT2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Sterol O-acyltransferase 2	polymer	530	60893.0	4	UniProt (O75908) Pfam (PF03062) In PDB	Homo sapiens (Human)	Acyl-coenzyme A:cholesterol acyltransferase 2,ACAT-2,Cholesterol acyltransferase 2
2	A, B, C, D	nevanimibe	non-polymer		421.6	4	Chemie (ROV)
3	A, B, C, D	CHOLESTEROL	non-polymer		386.7	8	Chemie (CLR)
4	A, B, C, D	OLEIC ACID	non-polymer		282.5	4	Chemie (OLA)

Sequence modifications

A, B, C, D: 2 - 522 (UniProt: O75908)

PDB	External Database	Details
Met -7	-	expression tag
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Lys 1	-	expression tag
Gly 14	Glu 14	variant
Ile 254	Thr 254	variant

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	243572.0
Non-Polymers*	Number of molecules	16
	Total formula weight	5909.5
All*	Total formula weight	249481.5

*Water molecules are not included.