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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7N6R

Structure of nevanimibe bound human ACAT2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000062molecular_functionfatty-acyl-CoA binding
A0004772molecular_functionsterol O-acyltransferase activity
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005903cellular_componentbrush border
A0006629biological_processlipid metabolic process
A0008202biological_processsteroid metabolic process
A0008203biological_processcholesterol metabolic process
A0008374molecular_functionO-acyltransferase activity
A0010742biological_processmacrophage derived foam cell differentiation
A0015485molecular_functioncholesterol binding
A0016020cellular_componentmembrane
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0030299biological_processintestinal cholesterol absorption
A0033344biological_processcholesterol efflux
A0034379biological_processvery-low-density lipoprotein particle assembly
A0034383biological_processlow-density lipoprotein particle clearance
A0034736molecular_functioncholesterol O-acyltransferase activity
A0042632biological_processcholesterol homeostasis
A0045797biological_processpositive regulation of intestinal cholesterol absorption
B0000062molecular_functionfatty-acyl-CoA binding
B0004772molecular_functionsterol O-acyltransferase activity
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005903cellular_componentbrush border
B0006629biological_processlipid metabolic process
B0008202biological_processsteroid metabolic process
B0008203biological_processcholesterol metabolic process
B0008374molecular_functionO-acyltransferase activity
B0010742biological_processmacrophage derived foam cell differentiation
B0015485molecular_functioncholesterol binding
B0016020cellular_componentmembrane
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0030299biological_processintestinal cholesterol absorption
B0033344biological_processcholesterol efflux
B0034379biological_processvery-low-density lipoprotein particle assembly
B0034383biological_processlow-density lipoprotein particle clearance
B0034736molecular_functioncholesterol O-acyltransferase activity
B0042632biological_processcholesterol homeostasis
B0045797biological_processpositive regulation of intestinal cholesterol absorption
C0000062molecular_functionfatty-acyl-CoA binding
C0004772molecular_functionsterol O-acyltransferase activity
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005903cellular_componentbrush border
C0006629biological_processlipid metabolic process
C0008202biological_processsteroid metabolic process
C0008203biological_processcholesterol metabolic process
C0008374molecular_functionO-acyltransferase activity
C0010742biological_processmacrophage derived foam cell differentiation
C0015485molecular_functioncholesterol binding
C0016020cellular_componentmembrane
C0016740molecular_functiontransferase activity
C0016746molecular_functionacyltransferase activity
C0030299biological_processintestinal cholesterol absorption
C0033344biological_processcholesterol efflux
C0034379biological_processvery-low-density lipoprotein particle assembly
C0034383biological_processlow-density lipoprotein particle clearance
C0034736molecular_functioncholesterol O-acyltransferase activity
C0042632biological_processcholesterol homeostasis
C0045797biological_processpositive regulation of intestinal cholesterol absorption
D0000062molecular_functionfatty-acyl-CoA binding
D0004772molecular_functionsterol O-acyltransferase activity
D0005515molecular_functionprotein binding
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005903cellular_componentbrush border
D0006629biological_processlipid metabolic process
D0008202biological_processsteroid metabolic process
D0008203biological_processcholesterol metabolic process
D0008374molecular_functionO-acyltransferase activity
D0010742biological_processmacrophage derived foam cell differentiation
D0015485molecular_functioncholesterol binding
D0016020cellular_componentmembrane
D0016740molecular_functiontransferase activity
D0016746molecular_functionacyltransferase activity
D0030299biological_processintestinal cholesterol absorption
D0033344biological_processcholesterol efflux
D0034379biological_processvery-low-density lipoprotein particle assembly
D0034383biological_processlow-density lipoprotein particle clearance
D0034736molecular_functioncholesterol O-acyltransferase activity
D0042632biological_processcholesterol homeostasis
D0045797biological_processpositive regulation of intestinal cholesterol absorption
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"P35610","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues100
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"P35610","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues112
DetailsTopological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues92
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"P35610","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues128
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"P35610","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues100
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"P35610","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues188
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"UniProtKB","id":"P35610","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues24
DetailsMotif: {"description":"FYXDWWN motif","evidences":[{"source":"UniProtKB","id":"P35610","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsActive site: {"evidences":[{"source":"PubMed","id":"16647063","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P35610","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsModified residue: {"description":"Cysteine sulfenic acid (-SOH); alternate","evidences":[{"source":"PubMed","id":"28604676","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues8
DetailsCross-link: {"description":"Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"28604676","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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