7N5C

6218 TCR in complex with H2Db PA with an engineered TCR-pMHC disulfide bond

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	H-2 class I histocompatibility antigen, D-B alpha chain	polymer	277	32174.8	1	UniProt (P01899) Pfam (PF00129) Pfam (PF07654)	Mus musculus (Mouse)	H-2D(B)
2	B (B)	Beta-2-microglobulin	polymer	100	11879.4	1	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	C (C)	peptide from Polymerase acidic protein	polymer	10	1160.3	1	UniProt (O89752)	Influenza A virus	RNA-directed RNA polymerase subunit P2
4	D (D)	Fusion protein of T cell receptor alpha variable 21-DV12 with T-cell receptor, sp3.4 alpha chain	polymer	204	22510.9	1	UniProt (A0A075B6C4) UniProt (K7N5N2) Pfam (PF07686) Pfam (PF09291)	Mus musculus (Mouse)	T-cell receptor,sp3.4 beta chain
5	E (E)	Fusion protein of T cell receptor beta, variable 29 and Human nkt tcr beta chain	polymer	240	27575.9	1	UniProt (A0A0G2LB96) UniProt (K7N5M4) Pfam (PF07686) Pfam (PF07654)	Mus musculus (Mouse)
6	F (E)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
7	G, H, I, J, K (A, B, C, D, E)	water	water		18.0	261	Chemie (HOH)

Sequence modifications

A: 1 - 276 (UniProt: P01899)

PDB	External Database	Details
Ser 277	-	expression tag

B: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

C: 1 - 10 (UniProt: O89752)

PDB	External Database	Details
Cys 4	Glu 227	engineered mutation

D: 1 - 106 (UniProt: A0A075B6C4)

D: 128 - 220 (UniProt: K7N5N2)
E: 1 - 107 (UniProt: A0A0G2LB96)

E: 111 - 253 (UniProt: K7N5M4)

PDB	External Database	Details
Leu 123	Thr 119	conflict

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.