7N0C
Cryo-EM structure of the monomeric form of SARS-CoV-2 nsp10-nsp14 (E191A)-RNA complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Non-structural protein 10 | polymer | 139 | 14802.9 | 1 | UniProt (P0DTD1) Pfam (PF09401) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | nsp10,Growth factor-like peptide,GFL |
| 2 | B | Proofreading exoribonuclease | polymer | 527 | 59829.4 | 1 | UniProt (P0DTD1) Pfam (PF06471) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | ExoN,Guanine-N7 methyltransferase,Non-structural protein 14,nsp14 |
| 3 | T | RNA (25-MER) | polymer | 37 | 11901.0 | 1 | Severe acute respiratory syndrome coronavirus 2 | ||
| 4 | D | RNA (24-MER) | polymer | 33 | 10459.3 | 1 | Severe acute respiratory syndrome coronavirus 2 | ||
| 5 | A, B | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 6 | B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
B: 1 - 527 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ala 191 | Glu 6116 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96992.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 375.7 | |
| All* | Total formula weight | 97368.3 |
