7N0C
Cryo-EM structure of the monomeric form of SARS-CoV-2 nsp10-nsp14 (E191A)-RNA complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0019079 | biological_process | viral genome replication |
| B | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004532 | molecular_function | RNA exonuclease activity |
| B | 0008168 | molecular_function | methyltransferase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01298 |
| Chain | Residue | Details |
| A | CYS120 | |
| A | CYS128 | |
| A | CYS130 | |
| B | ASP90 | |
| B | GLU92 | |
| B | ALA191 | |
| B | HIS268 | |
| B | ASP273 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 17 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36546776 |
| Chain | Residue | Details |
| B | CYS261 | |
| B | HIS264 | |
| B | HIS268 | |
| B | ASP273 | |
| B | CYS279 | |
| B | CYS452 | |
| B | CYS477 | |
| B | CYS484 | |
| B | HIS487 | |
| B | CYS210 | |
| B | CYS226 | |
| B | HIS229 | |
| B | HIS257 | |
| B | ASP90 | |
| B | GLU92 | |
| B | ALA191 | |
| B | CYS207 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01299 |
| Chain | Residue | Details |
| B | ASP331 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| B | GLN527 |
