7MZD
Cryo-EM structure of minimal TRPV1 with RTX bound in C2 state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, B, C) | Transient receptor potential cation channel subfamily V member 1 | polymer | 637 | 73016.4 | 4 | UniProt (O35433) Pfam (PF00023) Pfam (PF00520) | Rattus norvegicus (Rat) | TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like |
| 2 | E, H, I, J (A, D, B, C) | resiniferatoxin | non-polymer | 628.7 | 4 | Chemie (6EU) | |||
| 3 | F, G (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | K, L, M, N (A, D, B, C) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, D, B, C: 110 - 764 (UniProt: O35433)
| PDB | External Database | Details |
|---|---|---|
| Gly 105 | - | expression tag |
| Ala 106 | - | expression tag |
| Met 107 | - | expression tag |
| Gly 108 | - | expression tag |
| Ser 109 | - | expression tag |
| - | Asn 604 | deletion |
| - | Asn 605 | deletion |
| - | Ser 606 | deletion |
| - | Leu 607 | deletion |
| - | Pro 608 | deletion |
| - | Met 609 | deletion |
| - | Glu 610 | deletion |
| - | Ser 611 | deletion |
| - | Thr 612 | deletion |
| - | Pro 613 | deletion |
| - | His 614 | deletion |
| - | Lys 615 | deletion |
| - | Cys 616 | deletion |
| - | Arg 617 | deletion |
| - | Gly 618 | deletion |
| - | Ser 619 | deletion |
| - | Ala 620 | deletion |
| - | Cys 621 | deletion |
| - | Lys 622 | deletion |
| - | Pro 623 | deletion |
| - | Gly 624 | deletion |
| - | Asn 625 | deletion |
| - | Ser 626 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 292065.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2560.8 | |
| All* | Total formula weight | 294626.2 |
