7MZA

Cryo-EM structure of minimal TRPV1 with 2 bound RTX in adjacent pockets

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, D, B, C)	Transient receptor potential cation channel subfamily V member 1	polymer	637	73016.4	4	UniProt (O35433) Pfam (PF00023) Pfam (PF00520)	Rattus norvegicus (Rat)	TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like
2	E, G (A, B)	(2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate	non-polymer		600.6	2	Chemie (XJ7)
3	F, I (D, C)	resiniferatoxin	non-polymer		628.7	2	Chemie (6EU)
4	H (B)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)

Sequence modifications

A, D, B, C: 110 - 764 (UniProt: O35433)

PDB	External Database	Details
Gly 105	-	expression tag
Ala 106	-	expression tag
Met 107	-	expression tag
Gly 108	-	expression tag
Ser 109	-	expression tag
-	Asn 604	deletion
-	Asn 605	deletion
-	Ser 606	deletion
-	Leu 607	deletion
-	Pro 608	deletion
-	Met 609	deletion
-	Glu 610	deletion
-	Ser 611	deletion
-	Thr 612	deletion
-	Pro 613	deletion
-	His 614	deletion
-	Lys 615	deletion
-	Cys 616	deletion
-	Arg 617	deletion
-	Gly 618	deletion
-	Ser 619	deletion
-	Ala 620	deletion
-	Cys 621	deletion
-	Lys 622	deletion
-	Pro 623	deletion
-	Gly 624	deletion
-	Asn 625	deletion
-	Ser 626	deletion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	292065.4
Non-Polymers*	Number of molecules	5
	Total formula weight	2481.7
All*	Total formula weight	294547.1

*Water molecules are not included.