7MZA
Cryo-EM structure of minimal TRPV1 with 2 bound RTX in adjacent pockets
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, B, C) | Transient receptor potential cation channel subfamily V member 1 | polymer | 637 | 73016.4 | 4 | UniProt (O35433) Pfam (PF00023) Pfam (PF00520) | Rattus norvegicus (Rat) | TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like |
| 2 | E, G (A, B) | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate | non-polymer | 600.6 | 2 | Chemie (XJ7) | |||
| 3 | F, I (D, C) | resiniferatoxin | non-polymer | 628.7 | 2 | Chemie (6EU) PubChem (5311411) PubChem (5702546) PubChem (6324660) PubChem (44564218) PubChem (2733497) PubChem (176519982) PubChem (104826) PubChem (71718531) PubChem (5148108) PubChem (117893115) PubChem (53776296) PubChem (124525003) PubChem (57090162) PubChem (134688669) PubChem (15814491) PubChem (171342682) PubChem (92845090) PubChem (137635852) PubChem (139248250) | |||
| 4 | H (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) |
Sequence modifications
A, D, B, C: 110 - 764 (UniProt: O35433)
| PDB | External Database | Details |
|---|---|---|
| Gly 105 | - | expression tag |
| Ala 106 | - | expression tag |
| Met 107 | - | expression tag |
| Gly 108 | - | expression tag |
| Ser 109 | - | expression tag |
| - | Asn 604 | deletion |
| - | Asn 605 | deletion |
| - | Ser 606 | deletion |
| - | Leu 607 | deletion |
| - | Pro 608 | deletion |
| - | Met 609 | deletion |
| - | Glu 610 | deletion |
| - | Ser 611 | deletion |
| - | Thr 612 | deletion |
| - | Pro 613 | deletion |
| - | His 614 | deletion |
| - | Lys 615 | deletion |
| - | Cys 616 | deletion |
| - | Arg 617 | deletion |
| - | Gly 618 | deletion |
| - | Ser 619 | deletion |
| - | Ala 620 | deletion |
| - | Cys 621 | deletion |
| - | Lys 622 | deletion |
| - | Pro 623 | deletion |
| - | Gly 624 | deletion |
| - | Asn 625 | deletion |
| - | Ser 626 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 292065.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2481.7 | |
| All* | Total formula weight | 294547.1 |
