7MZ9
Cryo-EM structure of minimal TRPV1 with 1 partially bound RTX
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D, C, B | Transient receptor potential cation channel subfamily V member 1 | polymer | 637 | 73016.4 | 4 | UniProt (O35433) Pfam (PF00023) Pfam (PF00520) In PDB | Rattus norvegicus (Rat) | TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like |
2 | A | resiniferatoxin | non-polymer | 628.7 | 1 | Chemie (6EU) | |||
3 | D, C, B | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate | non-polymer | 600.6 | 3 | Chemie (XJ7) | |||
4 | B | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) |
Sequence modifications
A, D, C, B: 110 - 764 (UniProt: O35433)
PDB | External Database | Details |
---|---|---|
Gly 105 | - | expression tag |
Ala 106 | - | expression tag |
Met 107 | - | expression tag |
Gly 108 | - | expression tag |
Ser 109 | - | expression tag |
- | Asn 604 | deletion |
- | Asn 605 | deletion |
- | Ser 606 | deletion |
- | Leu 607 | deletion |
- | Pro 608 | deletion |
- | Met 609 | deletion |
- | Glu 610 | deletion |
- | Ser 611 | deletion |
- | Thr 612 | deletion |
- | Pro 613 | deletion |
- | His 614 | deletion |
- | Lys 615 | deletion |
- | Cys 616 | deletion |
- | Arg 617 | deletion |
- | Gly 618 | deletion |
- | Ser 619 | deletion |
- | Ala 620 | deletion |
- | Cys 621 | deletion |
- | Lys 622 | deletion |
- | Pro 623 | deletion |
- | Gly 624 | deletion |
- | Asn 625 | deletion |
- | Ser 626 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 292065.4 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 2453.6 | |
All* | Total formula weight | 294519.0 |