7MXV
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (ur)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (Z) | Exonuclease 1 | polymer | 358 | 40354.8 | 1 | UniProt (Q9UQ84) Pfam (PF00752) Pfam (PF00867) | Homo sapiens (Human) | hExo1, Exonuclease I, hExoI |
| 2 | B (A) | DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3') | polymer | 13 | 3951.6 | 1 | synthetic construct | ||
| 3 | C (B) | DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3') | polymer | 10 | 3045.0 | 1 | synthetic construct | ||
| 4 | D, E, F, G (Z) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 5 | H (Z) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | I, J, K (Z, A, B) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
Z: 1 - 346 (UniProt: Q9UQ84)
| PDB | External Database | Details |
|---|---|---|
| Glu 346 | - | expression tag |
| Asn 346 | - | expression tag |
| Leu 354 | - | expression tag |
| Tyr 355 | - | expression tag |
| Phe 356 | - | expression tag |
| Gln 357 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 47351.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 242.7 | |
| All* | Total formula weight | 47594.1 |
