7MOV
PTP1B 1-301 F225Y-R199N mutations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 308 | 35769.7 | 2 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (Human) | Protein-tyrosine phosphatase 1B,PTP-1B |
| 2 | C, D, E, J, K... (A, B) | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
| 3 | F, G, H (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 4 | I (B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 5 | Q, R (A, B) | water | water | 18.0 | 491 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 301 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| His -3 | - | expression tag |
| Met -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asn 199 | Arg 199 | engineered mutation |
| Tyr 225 | Phe 225 | engineered mutation |
| His 302 | - | expression tag |
| Asn 303 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71539.3 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1149.4 | |
| All* | Total formula weight | 72688.8 |
