7MOU
PTP1B F225Y-R199N-L195R
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 289 | 33550.3 | 1 | UniProt (P18031) Pfam (PF00102) In PDB | Homo sapiens (Human) | Protein-tyrosine phosphatase 1B,PTP-1B |
2 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
3 | A | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A: 1 - 284 (UniProt: P18031)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
His -3 | - | expression tag |
Met -2 | - | expression tag |
Ala -1 | - | expression tag |
Ser 0 | - | expression tag |
Arg 195 | Leu 195 | engineered mutation |
Asn 199 | Arg 199 | engineered mutation |
Tyr 225 | Phe 225 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 33550.3 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 412.7 | |
All* | Total formula weight | 33963.0 |