7ML4
RNA polymerase II initially transcribing complex (ITC)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (Q) | Transcription initiation factor IIF subunit alpha | polymer | 735 | 82320.6 | 1 | UniProt (P41895) Pfam (PF05793) | Saccharomyces cerevisiae (baker's yeast) | TFIIF-alpha,TFIIF large subunit,Transcription factor G 105 kDa subunit,P105 |
| 2 | B (R) | Transcription initiation factor IIF subunit beta | polymer | 398 | 46512.4 | 1 | UniProt (A0A6A5PZ00) Pfam (PF17683) Pfam (PF02270) UniProt (by SIFTS) (P41896) | Saccharomyces cerevisiae (baker's yeast) | |
| 3 | C (D) | DNA-directed RNA polymerase II subunit RPB4 | polymer | 221 | 25451.2 | 1 | UniProt (A0A6A5PTI6) Pfam (PF03874) UniProt (by SIFTS) (P20433) | Saccharomyces cerevisiae (baker's yeast) | |
| 4 | D (G) | DNA-directed RNA polymerase II subunit RPB7 | polymer | 171 | 19081.1 | 1 | UniProt (A0A6A5Q270) Pfam (PF03876) Pfam (PF00575) UniProt (by SIFTS) (P34087) | Saccharomyces cerevisiae (baker's yeast) | |
| 5 | E (M) | Transcription initiation factor IIB | polymer | 345 | 38257.3 | 1 | UniProt (P29055) Pfam (PF08271) Pfam (PF00382) | Saccharomyces cerevisiae (baker's yeast) | General transcription factor TFIIB,Transcription factor E |
| 6 | F (A) | DNA-directed RNA polymerase subunit | polymer | 1733 | 191821.6 | 1 | UniProt (A0A6A5Q1P2) Pfam (PF04997) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) Pfam (PF04992) Pfam (PF04990) Pfam (PF05001) UniProt (by SIFTS) (P04050) | Saccharomyces cerevisiae (baker's yeast) | |
| 7 | G (B) | DNA-directed RNA polymerase subunit beta | polymer | 1224 | 138937.3 | 1 | UniProt (A0A6A5Q4H2) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) UniProt (by SIFTS) (P08518) | Saccharomyces cerevisiae (baker's yeast) | |
| 8 | H (C) | DNA-directed RNA polymerase II subunit RPB3 | polymer | 318 | 35330.5 | 1 | UniProt (A0A6A5Q0Z3) Pfam (PF01193) Pfam (PF01000) UniProt (by SIFTS) (P16370) | Saccharomyces cerevisiae (baker's yeast) | |
| 9 | I (E) | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | polymer | 215 | 25117.1 | 1 | UniProt (A0A6A5Q456) Pfam (PF03871) Pfam (PF01191) UniProt (by SIFTS) (P20434) | Saccharomyces cerevisiae (baker's yeast) | |
| 10 | J (F) | DNA-directed RNA polymerases I,II,and III subunit RPABC2 | polymer | 155 | 17931.8 | 1 | UniProt (A0A6L0ZRI7) Pfam (PF01192) UniProt (by SIFTS) (P20435) | Saccharomyces cerevisiae (baker's yeast) | |
| 11 | K (H) | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 146 | 16525.4 | 1 | UniProt (A0A6A5Q8C2) Pfam (PF03870) UniProt (by SIFTS) (P20436) | Saccharomyces cerevisiae (baker's yeast) | |
| 12 | L (I) | DNA-directed RNA polymerase II subunit RPB9 | polymer | 122 | 14308.2 | 1 | UniProt (A0A7I9EWC2) Pfam (PF02150) Pfam (PF01096) UniProt (by SIFTS) (P27999) | Saccharomyces cerevisiae (baker's yeast) | |
| 13 | M (J) | DNA-directed RNA polymerases II subunit RPABC5 | polymer | 70 | 8290.7 | 1 | UniProt (A0A6A5Q7Q6) Pfam (PF01194) UniProt (by SIFTS) (P22139) | Saccharomyces cerevisiae (baker's yeast) | |
| 14 | N (K) | DNA-directed RNA polymerase II subunit RPB11 | polymer | 120 | 13633.5 | 1 | UniProt (A0A6A5Q7A1) Pfam (PF13656) UniProt (by SIFTS) (P38902) | Saccharomyces cerevisiae (baker's yeast) | |
| 15 | O (L) | DNA-directed RNA polymerases II subunit RPABC4 | polymer | 70 | 7730.0 | 1 | UniProt (A0A6A5PY05) Pfam (PF03604) UniProt (by SIFTS) (P40422) | Saccharomyces cerevisiae (baker's yeast) | |
| 16 | P (3) | BJ4_G0050160.mRNA.1.CDS.1 | polymer | 321 | 38188.4 | 1 | UniProt (A0A7I9BTI9) Pfam (PF06391) Pfam (PF17121) UniProt (by SIFTS) (Q03290) | Saccharomyces cerevisiae (baker's yeast) | SX2_G0047880.mRNA.1.CDS.1,Y55_G0047830.mRNA.1.CDS.1 |
| 17 | Q (0) | General transcription and DNA repair factor IIH helicase subunit XPD | polymer | 778 | 89899.0 | 1 | UniProt (A0A6A5Q1C1) Pfam (PF06733) Pfam (PF06777) Pfam (PF13307) UniProt (by SIFTS) (P06839) | Saccharomyces cerevisiae (baker's yeast) | |
| 18 | R (4) | General transcription and DNA repair factor IIH subunit TFB4 | polymer | 338 | 37430.3 | 1 | UniProt (A0A7I9C5C2) Pfam (PF03850) UniProt (by SIFTS) (Q12004) | Saccharomyces cerevisiae (baker's yeast) | RNA polymerase II transcription factor B subunit 4 |
| 19 | S (6) | General transcription and DNA repair factor IIH | polymer | 461 | 52024.7 | 1 | UniProt (A0A7I9FQL5) Pfam (PF04056) Pfam (PF07975) UniProt (by SIFTS) (Q04673) | Saccharomyces cerevisiae (baker's yeast) | |
| 20 | T (1) | Tfb1 | polymer | 543 | 58722.6 | 1 | Pfam (PF08567) Pfam (PF03909) UniProt (by SIFTS) (P32776) | Saccharomyces cerevisiae (Baker's yeast) | |
| 21 | U (7) | General transcription and DNA repair factor IIH helicase subunit XPB | polymer | 843 | 95461.7 | 1 | UniProt (Q00578) Pfam (PF13625) Pfam (PF04851) Pfam (PF16203) | Saccharomyces cerevisiae (baker's yeast) | TFIIH subunit XPB,DNA repair helicase RAD25,RNA polymerase II transcription factor B subunit SSL2,TFB subunit SSL2,Suppressor of stem-loop mutation 2 |
| 22 | V (5) | General transcription and DNA repair factor IIH subunit TFB5 | polymer | 72 | 8243.5 | 1 | UniProt (Q3E7C1) Pfam (PF06331) | Saccharomyces cerevisiae (baker's yeast) | TFIIH subunit TFB5,RNA polymerase II transcription factor B subunit 5 |
| 23 | W (2) | RNA polymerase II transcription factor B subunit 2 | polymer | 513 | 58602.3 | 1 | UniProt (A0A6A5Q2X3) Pfam (PF03849) Pfam (PF18307) UniProt (by SIFTS) (Q02939) | Saccharomyces cerevisiae (baker's yeast) | |
| 24 | X (X) | Transcription initiation factor IIE subunit beta | polymer | 328 | 37050.4 | 1 | UniProt (A0A6A5PS93) Pfam (PF02186) Pfam (PF18121) Pfam (PF22254) UniProt (by SIFTS) (P36145) | Saccharomyces cerevisiae (baker's yeast) | |
| 25 | Y (U) | Transcription initiation factor IIA large subunit | polymer | 286 | 32230.8 | 1 | UniProt (A0A6A5Q2T8) Pfam (PF03153) UniProt (by SIFTS) (P32773) | Saccharomyces cerevisiae (baker's yeast) | Y55_G0039490.mRNA.1.CDS.1 |
| 26 | Z (V) | Transcription initiation factor IIA subunit 2 | polymer | 122 | 13473.1 | 1 | UniProt (A0A6A5PRZ0) Pfam (PF02268) Pfam (PF02751) UniProt (by SIFTS) (P32774) | Saccharomyces cerevisiae (baker's yeast) | |
| 27 | AA (N) | non-template strand DNA | polymer | 38 | 11825.7 | 1 | Saccharomyces cerevisiae | ||
| 28 | BA (T) | template strand DNA | polymer | 148 | 34207.8 | 1 | Saccharomyces cerevisiae | ||
| 29 | CA (O) | TATA-box-binding protein | polymer | 240 | 27042.3 | 1 | UniProt (P13393) Pfam (PF00352) | Saccharomyces cerevisiae (baker's yeast) | TATA sequence-binding protein,TBP,TATA-binding factor,TATA-box factor,Transcription factor D,Transcription initiation factor TFIID TBP subunit |
| 30 | DA (W) | Transcription initiation factor IIE subunit alpha | polymer | 482 | 54804.8 | 1 | UniProt (A0A6A5PTU5) Pfam (PF02002) UniProt (by SIFTS) (P36100) | Saccharomyces cerevisiae (baker's yeast) | |
| 31 | EA (P) | RNA | polymer | 5 | 1649.1 | 1 | Saccharomyces cerevisiae | ||
| 32 | FA, GA, HA, JA, KA... (M, A, B, C, I...) | ZINC ION | non-polymer | 65.4 | 15 | Chemie (ZN) | |||
| 33 | IA (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 34 | PA (0) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) |
Sequence modifications
4: 1 - 338 (UniProt: A0A7I9C5C2)
6: 1 - 461 (UniProt: A0A7I9FQL5)
| PDB | External Database | Details |
|---|---|---|
| Unk 113 | Asp 113 | conflict |
| Unk 114 | Met 114 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Unk 412 | Ile 412 | conflict |
| Unk 413 | Leu 413 | conflict |
| Unk 414 | Lys 414 | conflict |
| Unk 415 | Asn 415 | conflict |
| Unk 416 | His 416 | conflict |
| Unk 417 | Lys 417 | conflict |
| Unk 418 | Asn 418 | conflict |
| Unk 419 | Asp 419 | conflict |
| Unk 420 | Lys 420 | conflict |
| Unk 421 | Leu 421 | conflict |
| Unk 422 | Leu 422 | conflict |
| Unk 423 | Thr 423 | conflict |
| Unk 424 | Ser 424 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 31 |
| Total formula weight | 1332105.0 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1357.1 | |
| All* | Total formula weight | 1333462.0 |
