7MKZ
PTP1B F225Y mutant, open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 308 | 35812.7 | 1 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (Human) | Protein-tyrosine phosphatase 1B,PTP-1B |
| 2 | B, C, D (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 3 | E, F, G, H (A) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | I (A) | water | water | 18.0 | 279 | Chemie (HOH) |
Sequence modifications
A: 1 - 301 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| His -3 | - | expression tag |
| Met -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Tyr 225 | Phe 225 | engineered mutation |
| His 302 | - | expression tag |
| Asn 303 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35812.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 418.1 | |
| All* | Total formula weight | 36230.8 |
