7MKX

Crystal Structure Analysis of human CDK2 and CCNA2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Cyclin-dependent kinase 2	polymer	303	34467.9	2	UniProt (P24941) Pfam (PF00069)	Homo sapiens (Human)	Cell division protein kinase 2,p33 protein kinase
2	B, D (B, D)	Cyclin-A2	polymer	268	30596.4	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984)	Homo sapiens (Human)	Cyclin-A,Cyclin A
3	E, F (A, C)	2-[(5-bromo-2-{4-[(cyanomethyl)sulfamoyl]anilino}pyrimidin-4-yl)amino]-6-fluorobenzamide	non-polymer		520.3	2	Chemie (ZGY)

Sequence modifications

A, C: 1 - 298 (UniProt: P24941)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

B, D: 171 - 432 (UniProt: P20248)

PDB	External Database	Details
Gly 165	-	expression tag
Pro 166	-	expression tag
Leu 167	-	expression tag
Gly 168	-	expression tag
Ser 169	-	expression tag
Met 170	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	130128.6
Non-Polymers*	Number of molecules	2
	Total formula weight	1040.7
All*	Total formula weight	131169.3

*Water molecules are not included.