7MK8
Crystal structure of a surface mutant of human fetal-specific CYP3A7 bound to dithiothreitol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Isoform 2 of Cytochrome P450 3A7 | polymer | 519 | 59614.3 | 2 | UniProt (P24462-2) Pfam (PF00067) UniProt (by SIFTS) (P24462) In PDB | Homo sapiens (Human) | CYPIIIA7,Cytochrome P450-HFLA,P450HLp2 |
2 | A, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
4 | A, B | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL | non-polymer | 154.3 | 2 | Chemie (DTV) | |||
5 | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A, B: 21 - 535 (UniProt: P24462-2)
PDB | External Database | Details |
---|---|---|
- | Leu 3 | deletion |
- | Ile 4 | deletion |
- | Pro 5 | deletion |
- | Asn 6 | deletion |
- | Leu 7 | deletion |
- | Ala 8 | deletion |
- | Val 9 | deletion |
- | Glu 10 | deletion |
- | Thr 11 | deletion |
- | Trp 12 | deletion |
- | Leu 13 | deletion |
- | Leu 14 | deletion |
- | Leu 15 | deletion |
- | Ala 16 | deletion |
- | Val 17 | deletion |
- | Ser 18 | deletion |
- | Leu 19 | deletion |
- | Ile 20 | deletion |
- | Leu 21 | deletion |
- | Leu 22 | deletion |
Gly 69 | Arg 69 | engineered mutation |
Gly 77 | Cys 77 | engineered mutation |
Glu 244 | Lys 244 | engineered mutation |
Ala 421 | Lys 421 | engineered mutation |
Ala 422 | Lys 422 | engineered mutation |
Ala 424 | Lys 424 | engineered mutation |
His 536 | - | expression tag |
His 537 | - | expression tag |
His 538 | - | expression tag |
His 539 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 119228.6 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1829.7 | |
All* | Total formula weight | 121058.3 |