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7MII

Human CTPS2 bound to inhibitor T35

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, E)
CTP synthase 2polymer58665759.44UniProt (Q9NRF8)
Pfam (PF06418)
Pfam (PF00117)
Pfam (PF07722)
Homo sapiens (Human)CTP synthetase 2,UTP--ammonia ligase 2
2E, J, M, R
(A, B, C, E)
2-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}-2-methyl-N-{5-[6-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl}propanamidenon-polymer512.54Chemie (ZFY)
3F, K, N, S
(A, B, C, E)
URIDINE 5'-TRIPHOSPHATEnon-polymer484.14Chemie (UTP)
4G, L, O, T
(A, B, C, E)
GLUTAMINEnon-polymer146.14Chemie (GLN)
5H, I, P, Q
(A, B, C, E)
MAGNESIUM IONnon-polymer24.34Chemie (MG)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight263037.7
Non-Polymers*Number of molecules16
Total formula weight4668.5
All*Total formula weight267706.2
*Water molecules are not included.

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PDB entries from 2025-12-24

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