7MII

Human CTPS2 bound to inhibitor T35

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003883	molecular_function	CTP synthase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0090407	biological_process	organophosphate biosynthetic process
A	0097268	cellular_component	cytoophidium
B	0003883	molecular_function	CTP synthase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0090407	biological_process	organophosphate biosynthetic process
B	0097268	cellular_component	cytoophidium
C	0003883	molecular_function	CTP synthase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0090407	biological_process	organophosphate biosynthetic process
C	0097268	cellular_component	cytoophidium
E	0003883	molecular_function	CTP synthase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0006220	biological_process	pyrimidine nucleotide metabolic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0090407	biological_process	organophosphate biosynthetic process
E	0097268	cellular_component	cytoophidium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"For GATase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00605","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PK4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PK7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PK7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PK7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---