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7MIF

Human CTPS1 bound to inhibitor R80

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(C, G, H, I)
CTP synthase 1polymer59166777.34UniProt (P17812)
Pfam (PF06418)
Pfam (PF00117)
Pfam (PF07722)
Homo sapiens (Human)CTP synthetase 1, UTP--ammonia ligase 1
2E, K, M, S
(C, G, H, I)
GLUTAMINEnon-polymer146.14Chemie (GLN)
3F, L, O, T
(C, G, H, I)
N-(1-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}cyclopropyl)-5-(6-ethoxypyrazin-2-yl)pyridine-2-carboxamidenon-polymer486.64Chemie (ZG4)
4G, I, N, P
(C, G, H)
MAGNESIUM IONnon-polymer24.34Chemie (MG)
5H, J, Q, R
(C, G, H, I)
URIDINE 5'-TRIPHOSPHATEnon-polymer484.14Chemie (UTP)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight267109.2
Non-Polymers*Number of molecules16
Total formula weight4564.6
All*Total formula weight271673.8
*Water molecules are not included.

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PDB entries from 2025-06-18

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