Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7MIF

Human CTPS1 bound to inhibitor R80

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0002376	biological_process	immune system process
C	0003883	molecular_function	CTP synthase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0009410	biological_process	response to xenobiotic stimulus
C	0016020	cellular_component	membrane
C	0016874	molecular_function	ligase activity
C	0019637	biological_process	organophosphate metabolic process
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0042098	biological_process	T cell proliferation
C	0042100	biological_process	B cell proliferation
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0097268	cellular_component	cytoophidium
G	0002376	biological_process	immune system process
G	0003883	molecular_function	CTP synthase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006139	biological_process	nucleobase-containing compound metabolic process
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006241	biological_process	CTP biosynthetic process
G	0006541	biological_process	glutamine metabolic process
G	0009410	biological_process	response to xenobiotic stimulus
G	0016020	cellular_component	membrane
G	0016874	molecular_function	ligase activity
G	0019637	biological_process	organophosphate metabolic process
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0042098	biological_process	T cell proliferation
G	0042100	biological_process	B cell proliferation
G	0042802	molecular_function	identical protein binding
G	0044210	biological_process	'de novo' CTP biosynthetic process
G	0097268	cellular_component	cytoophidium
H	0002376	biological_process	immune system process
H	0003883	molecular_function	CTP synthase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006139	biological_process	nucleobase-containing compound metabolic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006241	biological_process	CTP biosynthetic process
H	0006541	biological_process	glutamine metabolic process
H	0009410	biological_process	response to xenobiotic stimulus
H	0016020	cellular_component	membrane
H	0016874	molecular_function	ligase activity
H	0019637	biological_process	organophosphate metabolic process
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0042098	biological_process	T cell proliferation
H	0042100	biological_process	B cell proliferation
H	0042802	molecular_function	identical protein binding
H	0044210	biological_process	'de novo' CTP biosynthetic process
H	0097268	cellular_component	cytoophidium
I	0002376	biological_process	immune system process
I	0003883	molecular_function	CTP synthase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006139	biological_process	nucleobase-containing compound metabolic process
I	0006221	biological_process	pyrimidine nucleotide biosynthetic process
I	0006241	biological_process	CTP biosynthetic process
I	0006541	biological_process	glutamine metabolic process
I	0009410	biological_process	response to xenobiotic stimulus
I	0016020	cellular_component	membrane
I	0016874	molecular_function	ligase activity
I	0019637	biological_process	organophosphate metabolic process
I	0019856	biological_process	pyrimidine nucleobase biosynthetic process
I	0042098	biological_process	T cell proliferation
I	0042100	biological_process	B cell proliferation
I	0042802	molecular_function	identical protein binding
I	0044210	biological_process	'de novo' CTP biosynthetic process
I	0097268	cellular_component	cytoophidium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: For GATase activity => ECO:0000250

Chain	Residue	Details
C	CYS399
I	CYS399
I	HIS526
I	GLU528
C	HIS526
C	GLU528
G	CYS399
G	HIS526
G	GLU528
H	CYS399
H	HIS526
H	GLU528

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
C	LYS100
G	LYS100
H	LYS100
I	LYS100

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21406692

Chain	Residue	Details
C	SER562
G	SER562
H	SER562
I	SER562

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
C	SER568
C	SER587
G	SER568
G	SER587
H	SER568
H	SER587
I	SER568
I	SER587

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332

Chain	Residue	Details
C	SER571
G	SER571
H	SER571
I	SER571

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:21406692

Chain	Residue	Details
C	SER573
G	SER573
H	SER573
I	SER573

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
C	SER574
G	SER574
H	SER574
I	SER574

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	SER575
G	SER575
H	SER575
I	SER575

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P70698

Chain	Residue	Details
C	SER578
G	SER578
H	SER578
I	SER578

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)