7MCJ

Crystal Structure of S-adenosylmethionine-dependent methyltransferase UmaA from Mycobacterium tuberculosis in complex with compound 8918

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	S-adenosylmethionine-dependent methyltransferase UmaA	polymer	294	34162.7	2	UniProt (Q6MX39) Pfam (PF02353) In PDB	Mycobacterium tuberculosis	SAM-dependent methyltransferase UmaA
2	A, B	N-(2,6-diethylphenyl)-N'-(N-ethylcarbamimidoyl)urea	non-polymer		262.4	2	Chemie (FD7)
3	A, B	NITRATE ION	non-polymer		62.0	2	Chemie (NO3)
4	A, B	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
7		water	water		18.0	294	Chemie (HOH)

Sequence modifications

A, B: 1 - 286 (UniProt: Q6MX39)

PDB	External Database	Details
Met -7	-	initiating methionine
Ala -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68325.5
Non-Polymers*	Number of molecules	11
	Total formula weight	954.4
All*	Total formula weight	69279.9

*Water molecules are not included.