7MBX
Human Cholecystokinin 1 receptor (CCK1R) Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45699.4 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P54311) Pfam (PF00400) | Rattus norvegicus (Rat) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D (N) | Nanobody35 | polymer | 138 | 15140.7 | 1 | Lama glama | ||
| 5 | E (P) | Cholecystokinin-8 | polymer | 9 | 1142.3 | 1 | UniProt (P06307) | Homo sapiens | CCK-8 |
| 6 | F (R) | Cholecystokinin receptor type A | polymer | 435 | 48860.0 | 1 | UniProt (P32238) Pfam (PF09193) Pfam (PF00001) | Homo sapiens (Human) | CCK-A receptor,CCK-AR,Cholecystokinin-1 receptor,CCK1-R |
| 7 | G (R) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) | |||
| 8 | H, I, J, K, L (A, B, G, N, R) | water | water | 18.0 | 61 | Chemie (HOH) |
Sequence modifications
A: 1 - 394 (UniProt: P63092)
P: 1 - 8 (UniProt: P06307)
R: 2 - 428 (UniProt: P32238)
| PDB | External Database | Details |
|---|---|---|
| Asn 54 | Ser 54 | conflict |
| Ala 226 | Gly 226 | conflict |
| Ala 268 | Glu 268 | conflict |
| Lys 271 | Asn 271 | conflict |
| Asp 274 | Lys 274 | conflict |
| Lys 280 | Arg 280 | conflict |
| Asp 284 | Thr 284 | conflict |
| Thr 285 | Ile 285 | conflict |
| Ser 366 | Ala 366 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Nh2 9 | - | amidation |
| PDB | External Database | Details |
|---|---|---|
| His 429 | - | expression tag |
| His 430 | - | expression tag |
| His 431 | - | expression tag |
| His 432 | - | expression tag |
| His 433 | - | expression tag |
| His 434 | - | expression tag |
| His 435 | - | expression tag |
| His 436 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 156120.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 486.7 | |
| All* | Total formula weight | 156607.3 |
