7MAR
Drug Resistant HIV-1 Protease (L10F, M46I, I47V, I50V, F53L, L63P, I72V, G73S, V82I, I85V) in Complex with DRV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | D, A, B, C | Protease | polymer | 99 | 10785.7 | 4 | UniProt (P03367) Pfam (PF00077) In PDB | Human immunodeficiency virus type 1 group M subtype B (HIV-1) | PR,Retropepsin |
| 2 | A, C | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 2 | Chemie (017) | |||
| 3 | water | water | 18.0 | 359 | Chemie (HOH) |
Sequence modifications
D, A, B, C: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 507 | conflict |
| Phe 10 | Leu 510 | engineered mutation |
| Asn 37 | Ser 537 | conflict |
| Ile 46 | Met 546 | engineered mutation |
| Val 47 | Ile 547 | engineered mutation |
| Val 50 | Ile 550 | engineered mutation |
| Leu 53 | Phe 553 | engineered mutation |
| Pro 63 | Leu 563 | engineered mutation |
| Val 72 | Ile 572 | engineered mutation |
| Ser 73 | Gly 573 | engineered mutation |
| Ile 82 | Val 582 | engineered mutation |
| Val 85 | Ile 585 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43142.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1095.3 | |
| All* | Total formula weight | 44238.1 |
