7MAR
Drug Resistant HIV-1 Protease (L10F, M46I, I47V, I50V, F53L, L63P, I72V, G73S, V82I, I85V) in Complex with DRV
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue 017 A 101 |
| Chain | Residue |
| A | ASP25 |
| A | HOH207 |
| B | ARG8 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP30 |
| B | VAL47 |
| B | GLY48 |
| B | GLY49 |
| B | HOH106 |
| A | GLY27 |
| B | HOH140 |
| A | ASP29 |
| A | ASP30 |
| A | VAL47 |
| A | GLY48 |
| A | VAL50 |
| A | ILE82 |
| A | ILE84 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue 017 C 101 |
| Chain | Residue |
| C | ASP25 |
| C | GLY27 |
| C | ALA28 |
| C | ASP29 |
| C | ASP30 |
| C | GLY48 |
| C | GLY49 |
| C | VAL50 |
| C | ILE84 |
| C | HOH234 |
| D | ASP25 |
| D | GLY27 |
| D | ALA28 |
| D | ASP30 |
| D | VAL32 |
| D | GLY48 |
| D | GLY49 |
| D | PRO81 |
| D | ILE82 |
| D | HOH102 |
| D | HOH114 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL |
| Chain | Residue | Details |
| D | ALA22-LEU33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 276 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
