7M8W
XFEL crystal structure of the prostaglandin D2 receptor CRTH2 in complex with 15R-methyl-PGD2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prostaglandin D2 receptor 2, Endolysin chimera | polymer | 470 | 52228.7 | 1 | UniProt (Q9Y5Y4) UniProt (D9IEF7) Pfam (PF00001) | Homo sapiens (Human) | |
| 2 | B (A) | 15R-methyl-prostaglandin D2 | non-polymer | 366.5 | 1 | Chemie (YSS) PubChem (177613078) PubChem (177671693) PubChem (35021269) PubChem (35021275) PubChem (35021279) PubChem (35021296) PubChem (35021302) PubChem (44216448) PubChem (44378879) PubChem (44390930) PubChem (23032554) PubChem (35021290) PubChem (53394114) PubChem (70687200) PubChem (71434074) PubChem (3069815) PubChem (3246841) PubChem (177675576) PubChem (5283097) PubChem (5283051) PubChem (132282638) PubChem (122176719) PubChem (9999002) PubChem (124406604) PubChem (124406605) PubChem (124629380) PubChem (124629381) PubChem (132282639) PubChem (142894488) PubChem (142894504) PubChem (146158034) PubChem (156358699) PubChem (156681967) PubChem (156681972) | |||
| 3 | C (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 4 | D (A) | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) PubChem (31348) | |||
| 5 | E, F, G, H, I (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 6 | J (A) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A: 1 - 236 (UniProt: Q9Y5Y4)
A: 1002 - 1055 (UniProt: D9IEF7)
A: 1061 - 1161 (UniProt: D9IEF7)
A: 238 - 339 (UniProt: Q9Y5Y4)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ala 25 | Asn 25 | engineered mutation |
| Ala 204 | Val 204 | variant |
A: 1061 - 1161 (UniProt: D9IEF7)
| PDB | External Database | Details |
|---|---|---|
| Gly 1056 | - | linker |
| Gly 1057 | - | linker |
| Ser 1058 | - | linker |
| Gly 1059 | - | linker |
| Gly 1060 | - | linker |
| Ala 1097 | Cys 97 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 900 | - | linker |
| Asp 901 | - | linker |
| Leu 902 | - | linker |
| Gly 903 | - | linker |
| Leu 904 | - | linker |
| Gln 905 | - | linker |
| His 906 | - | linker |
| Arg 907 | - | linker |
| Leu 340 | - | expression tag |
| Glu 341 | - | expression tag |
| Val 342 | - | expression tag |
| Leu 343 | - | expression tag |
| Phe 344 | - | expression tag |
| Gln 345 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52228.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1058.9 | |
| All* | Total formula weight | 53287.6 |
