7M8L

EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, G, M (A, B, C)	Virion spike glycoprotein 1	polymer	313	34978.6	3	UniProt (A0A1C4HDV6) Pfam (PF01611) UniProt (by SIFTS) (Q05320)	Ebola virus
2	B, H, N (G, H, I)	rEBOV-442 Fab heavy chain	polymer	239	25179.2	3		Homo sapiens (Human)
3	C, I, O (J, K, L)	rEBOV-442 Fab light chain	polymer	215	23715.3	3		Homo sapiens (Human)
4	D, J, P (D, E, F)	Virion spike glycoprotein 2	polymer	203	22158.6	3	UniProt (A0A0E3XK95) Pfam (PF22307) UniProt (by SIFTS) (Q05320)	Ebola virus
5	E, K, Q (M, N, O)	rEBOV-515 Fab heavy chain	polymer	225	24047.8	3		Homo sapiens (Human)
6	F, L, R (P, Q, R)	rEBOV-515 Fab light chain	polymer	214	23528.1	3		Homo sapiens (Human)
7	AA, S, U, V, X... (a, S, U, V, X...)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	6	In PDB GlyTouCan (G22768VO)
8	T, W, Z (T, W, Z)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
9	BA, CA, DA, EA, FA... (A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)

Sequence modifications

A, B, C: 32 - 309 (UniProt: A0A1C4HDV6)

PDB	External Database	Details
Met -3	-	expression tag
Asp -2	-	expression tag
Ala -1	-	expression tag
Met 0	-	expression tag
Lys 1	-	expression tag
Arg 2	-	expression tag
Gly 3	-	expression tag
Leu 4	-	expression tag
Cys 5	-	expression tag
Cys 6	-	expression tag
Val 7	-	expression tag
Leu 8	-	expression tag
Leu 9	-	expression tag
Leu 10	-	expression tag
Cys 11	-	expression tag
Gly 12	-	expression tag
Ala 13	-	expression tag
Val 14	-	expression tag
Phe 15	-	expression tag
Val 16	-	expression tag
Ser 17	-	expression tag
Pro 18	-	expression tag
Ser 19	-	expression tag
Gln 20	-	expression tag
Glu 21	-	expression tag
Ile 22	-	expression tag
His 23	-	expression tag
Ala 24	-	expression tag
Arg 25	-	expression tag
Phe 26	-	expression tag
Arg 27	-	expression tag
Arg 28	-	expression tag
Gly 29	-	expression tag
Ala 30	-	expression tag
Arg 31	-	expression tag

D, E, F: 461 - 629 (UniProt: A0A0E3XK95)

PDB	External Database	Details
Asp 630	-	expression tag
Asp 631	-	expression tag
Asp 632	-	expression tag
Lys 633	-	expression tag
Ala 634	-	expression tag
Gly 635	-	expression tag
Trp 636	-	expression tag
Ser 637	-	expression tag
His 638	-	expression tag
Pro 639	-	expression tag
Gln 640	-	expression tag
Phe 641	-	expression tag
Glu 642	-	expression tag
Lys 643	-	expression tag
Gly 644	-	expression tag
Gly 645	-	expression tag
Gly 646	-	expression tag
Ser 647	-	expression tag
Gly 648	-	expression tag
Gly 649	-	expression tag
Gly 650	-	expression tag
Ser 651	-	expression tag
Gly 652	-	expression tag
Gly 653	-	expression tag
Gly 654	-	expression tag
Ser 655	-	expression tag
Trp 656	-	expression tag
Ser 657	-	expression tag
His 658	-	expression tag
Pro 659	-	expression tag
Gln 660	-	expression tag
Phe 661	-	expression tag
Glu 662	-	expression tag
Lys 663	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	460823.0
Branched	Number of molecules	9
	Total formula weight	6738.1
Non-Polymers*	Number of molecules	6
	Total formula weight	1327.2
All*	Total formula weight	468888.4

*Water molecules are not included.