7M8I

Human CYP11B2 and human adrenodoxin in complex with fadrozole

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Adrenodoxin, Cytochrome P450 11B2, mitochondrial fusion enzyme	polymer	609	69326.8	3	UniProt (P10109) UniProt (P19099) Pfam (PF00111) Pfam (PF00067) In PDB	Homo sapiens (Human)	Adrenal ferredoxin,Ferredoxin-1,Hepatoredoxin,Aldosterone synthase,ALDOS,Aldosterone-synthesizing enzyme,CYPXIB2,Corticosterone 18-monooxygenase,CYP11B2,Cytochrome P-450Aldo,Cytochrome P-450C18,Steroid 11-beta-hydroxylase,Steroid 18-hydroxylase
2	A, B, C	FE2/S2 (INORGANIC) CLUSTER	non-polymer		175.8	3	Chemie (FES)
3	A, B, C	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	3	Chemie (HEM)
4	A, B, C	4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile	non-polymer		223.3	3	Chemie (0T3)
5		water	water		18.0	1	Chemie (HOH)

Sequence modifications

A, B, C: 61 - 184 (UniProt: P10109)

PDB	External Database	Details
Met 60	-	initiating methionine
Ala 185	-	linker
Ala 186	-	linker
Lys 187	-	linker
Lys 188	-	linker
Thr 189	-	linker
Ser 190	-	linker
Ser 191	-	linker

A, B, C: 1031 - 1503 (UniProt: P19099)

PDB	External Database	Details
His 1504	-	expression tag
His 1505	-	expression tag
His 1506	-	expression tag
His 1507	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	207980.5
Non-Polymers*	Number of molecules	9
	Total formula weight	3046.7
All*	Total formula weight	211027.2

*Water molecules are not included.