7M8I
Human CYP11B2 and human adrenodoxin in complex with fadrozole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Adrenodoxin, Cytochrome P450 11B2, mitochondrial fusion enzyme | polymer | 609 | 69326.8 | 3 | UniProt (P10109) UniProt (P19099) Pfam (PF00111) Pfam (PF00067) | Homo sapiens (Human) | Adrenal ferredoxin,Ferredoxin-1,Hepatoredoxin,Aldosterone synthase,ALDOS,Aldosterone-synthesizing enzyme,CYPXIB2,Corticosterone 18-monooxygenase,CYP11B2,Cytochrome P-450Aldo,Cytochrome P-450C18,Steroid 11-beta-hydroxylase,Steroid 18-hydroxylase |
| 2 | D, G, J (A, B, C) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 3 | Chemie (FES) | |||
| 3 | E, H, K (A, B, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 3 | Chemie (HEM) | |||
| 4 | F, I, L (A, B, C) | 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile | non-polymer | 223.3 | 3 | Chemie (0T3) | |||
| 5 | M (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B, C: 61 - 184 (UniProt: P10109)
A, B, C: 1031 - 1503 (UniProt: P19099)
| PDB | External Database | Details |
|---|---|---|
| Met 60 | - | initiating methionine |
| Ala 185 | - | linker |
| Ala 186 | - | linker |
| Lys 187 | - | linker |
| Lys 188 | - | linker |
| Thr 189 | - | linker |
| Ser 190 | - | linker |
| Ser 191 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| His 1504 | - | expression tag |
| His 1505 | - | expression tag |
| His 1506 | - | expression tag |
| His 1507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 207980.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 3046.7 | |
| All* | Total formula weight | 211027.2 |
