Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7M8I

Human CYP11B2 and human adrenodoxin in complex with fadrozole

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002017	biological_process	regulation of blood volume by renal aldosterone
A	0003091	biological_process	renal water homeostasis
A	0004497	molecular_function	monooxygenase activity
A	0004507	molecular_function	steroid 11-beta-monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006700	biological_process	C21-steroid hormone biosynthetic process
A	0006704	biological_process	glucocorticoid biosynthetic process
A	0006705	biological_process	mineralocorticoid biosynthetic process
A	0008203	biological_process	cholesterol metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016125	biological_process	sterol metabolic process
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0032342	biological_process	aldosterone biosynthetic process
A	0032870	biological_process	cellular response to hormone stimulus
A	0034650	biological_process	cortisol metabolic process
A	0034651	biological_process	cortisol biosynthetic process
A	0035865	biological_process	cellular response to potassium ion
A	0046872	molecular_function	metal ion binding
A	0047783	molecular_function	corticosterone 18-monooxygenase activity
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
A	0055075	biological_process	potassium ion homeostasis
A	0055078	biological_process	sodium ion homeostasis
A	0071375	biological_process	cellular response to peptide hormone stimulus
A	0140647	biological_process	P450-containing electron transport chain
A	1901615	biological_process	organic hydroxy compound metabolic process
B	0002017	biological_process	regulation of blood volume by renal aldosterone
B	0003091	biological_process	renal water homeostasis
B	0004497	molecular_function	monooxygenase activity
B	0004507	molecular_function	steroid 11-beta-monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006629	biological_process	lipid metabolic process
B	0006694	biological_process	steroid biosynthetic process
B	0006700	biological_process	C21-steroid hormone biosynthetic process
B	0006704	biological_process	glucocorticoid biosynthetic process
B	0006705	biological_process	mineralocorticoid biosynthetic process
B	0008203	biological_process	cholesterol metabolic process
B	0008395	molecular_function	steroid hydroxylase activity
B	0016125	biological_process	sterol metabolic process
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0020037	molecular_function	heme binding
B	0032342	biological_process	aldosterone biosynthetic process
B	0032870	biological_process	cellular response to hormone stimulus
B	0034650	biological_process	cortisol metabolic process
B	0034651	biological_process	cortisol biosynthetic process
B	0035865	biological_process	cellular response to potassium ion
B	0046872	molecular_function	metal ion binding
B	0047783	molecular_function	corticosterone 18-monooxygenase activity
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051537	molecular_function	2 iron, 2 sulfur cluster binding
B	0055075	biological_process	potassium ion homeostasis
B	0055078	biological_process	sodium ion homeostasis
B	0071375	biological_process	cellular response to peptide hormone stimulus
B	0140647	biological_process	P450-containing electron transport chain
B	1901615	biological_process	organic hydroxy compound metabolic process
C	0002017	biological_process	regulation of blood volume by renal aldosterone
C	0003091	biological_process	renal water homeostasis
C	0004497	molecular_function	monooxygenase activity
C	0004507	molecular_function	steroid 11-beta-monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006629	biological_process	lipid metabolic process
C	0006694	biological_process	steroid biosynthetic process
C	0006700	biological_process	C21-steroid hormone biosynthetic process
C	0006704	biological_process	glucocorticoid biosynthetic process
C	0006705	biological_process	mineralocorticoid biosynthetic process
C	0008203	biological_process	cholesterol metabolic process
C	0008395	molecular_function	steroid hydroxylase activity
C	0016125	biological_process	sterol metabolic process
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0020037	molecular_function	heme binding
C	0032342	biological_process	aldosterone biosynthetic process
C	0032870	biological_process	cellular response to hormone stimulus
C	0034650	biological_process	cortisol metabolic process
C	0034651	biological_process	cortisol biosynthetic process
C	0035865	biological_process	cellular response to potassium ion
C	0046872	molecular_function	metal ion binding
C	0047783	molecular_function	corticosterone 18-monooxygenase activity
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051537	molecular_function	2 iron, 2 sulfur cluster binding
C	0055075	biological_process	potassium ion homeostasis
C	0055078	biological_process	sodium ion homeostasis
C	0071375	biological_process	cellular response to peptide hormone stimulus
C	0140647	biological_process	P450-containing electron transport chain
C	1901615	biological_process	organic hydroxy compound metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGMRQCLG

Chain	Residue	Details
A	PHE1443-GLY1452

site_id	PS00814
Number of Residues	11
Details	ADX Adrenodoxin family, iron-sulfur binding region signature. CegTlACSTCH

Chain	Residue	Details
A	CYS106-HIS116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	CYS106
C	CYS112
C	CYS115
C	CYS152
A	CYS112
A	CYS115
A	CYS152
B	CYS106
B	CYS112
B	CYS115
B	CYS152
C	CYS106

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P46656

Chain	Residue	Details
A	SER63
B	SER63
C	SER63

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P46656

Chain	Residue	Details
A	LYS66
B	LYS66
C	LYS66

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P46656

Chain	Residue	Details
A	LYS158
B	LYS158
C	LYS158

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER177
B	SER177
C	SER177

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:23322723, ECO:0007744\|PDB:4DVQ

Chain	Residue	Details
A	PHE1381
B	PHE1381
C	PHE1381

site_id	SWS_FT_FI7
Number of Residues	3
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:23322723, ECO:0007744\|PDB:4DVQ, ECO:0007744\|PDB:4FDH

Chain	Residue	Details
A	CYS1450
B	CYS1450
C	CYS1450

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)