7M74
ATP-bound AMP-activated protein kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | polymer | 484 | 56004.4 | 1 | Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) UniProt (by SIFTS) (Q13131) In PDB | Homo sapiens (Human) | |
| 2 | B | 5'-AMP-activated protein kinase subunit beta-2 | polymer | 198 | 22384.7 | 1 | UniProt (O43741) Pfam (PF16561) Pfam (PF04739) In PDB | Homo sapiens (human) | AMPK subunit beta-2 |
| 3 | G | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 306 | 34833.4 | 1 | UniProt (P54619) Pfam (PF00571) In PDB | Homo sapiens (human) | AMPKg |
| 4 | M | Maltose/maltodextrin ABC transporter substrate-binding protein MalE | polymer | 373 | 40827.1 | 1 | UniProt (A0A6D0N546) Pfam (PF01547) UniProt (by SIFTS) (P0AEX9) In PDB | Escherichia coli | |
| 5 | L | Fab light chain | polymer | 211 | 22794.2 | 1 | Homo sapiens | ||
| 6 | H | Fab heavy chain | polymer | 228 | 24466.4 | 1 | Homo sapiens | ||
| 7 | N | Nanobody | polymer | 120 | 13159.4 | 1 | Lama glama | ||
| 8 | D | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | |||
| 9 | A | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | non-polymer | 399.5 | 1 | Chemie (TAK) | |||
| 10 | G | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 11 | G | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 12 | G | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) |
Sequence modifications
B: 76 - 272 (UniProt: O43741)
G: 24 - 327 (UniProt: P54619)
M: 0 - 366 (UniProt: A0A6D0N546)
| PDB | External Database | Details |
|---|---|---|
| Met 75 | - | initiating methionine |
| Ala 199 | Glu 199 | conflict |
| Ala 200 | Glu 200 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 22 | - | expression tag |
| Gly 23 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Ala 82 | Asp 108 | conflict |
| Ala 83 | Lys 109 | conflict |
| Ala 239 | Lys 265 | conflict |
| Asn 367 | - | expression tag |
| Ala 368 | - | expression tag |
| Ala 369 | - | expression tag |
| Glu 370 | - | expression tag |
| Phe 371 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 214469.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1681.1 | |
| All* | Total formula weight | 216493.0 |
