7M74
ATP-bound AMP-activated protein kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | polymer | 484 | 56004.4 | 1 | Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) UniProt (by SIFTS) (Q13131) | Homo sapiens (Human) | |
| 2 | B (B) | 5'-AMP-activated protein kinase subunit beta-2 | polymer | 198 | 22384.7 | 1 | UniProt (O43741) Pfam (PF16561) Pfam (PF04739) | Homo sapiens (human) | AMPK subunit beta-2 |
| 3 | C (G) | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 306 | 34833.4 | 1 | UniProt (P54619) Pfam (PF00571) | Homo sapiens (human) | AMPKg |
| 4 | D (M) | Maltose/maltodextrin ABC transporter substrate-binding protein MalE | polymer | 373 | 40827.1 | 1 | UniProt (A0A6D0N546) Pfam (PF01547) UniProt (by SIFTS) (P0AEX9) | Escherichia coli | |
| 5 | E (L) | Fab light chain | polymer | 211 | 22794.2 | 1 | Homo sapiens | ||
| 6 | F (H) | Fab heavy chain | polymer | 228 | 24466.4 | 1 | Homo sapiens | ||
| 7 | G (N) | Nanobody | polymer | 120 | 13159.4 | 1 | Lama glama | ||
| 8 | H (D) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | |||
| 9 | I (A) | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | non-polymer | 399.5 | 1 | Chemie (TAK) PubChem (11524144) | |||
| 10 | J (G) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 11 | K (G) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 12 | L (G) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (40459109) PubChem (46875232) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (45358029) PubChem (177678969) PubChem (6083) PubChem (46874558) PubChem (1549371) PubChem (92144436) PubChem (57358045) PubChem (12358354) PubChem (57879893) PubChem (57879902) PubChem (224) PubChem (122197642) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (5316444) PubChem (5742864) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505) |
Sequence modifications
B: 76 - 272 (UniProt: O43741)
G: 24 - 327 (UniProt: P54619)
M: 0 - 366 (UniProt: A0A6D0N546)
| PDB | External Database | Details |
|---|---|---|
| Met 75 | - | initiating methionine |
| Ala 199 | Glu 199 | conflict |
| Ala 200 | Glu 200 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 22 | - | expression tag |
| Gly 23 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Ala 82 | Asp 108 | conflict |
| Ala 83 | Lys 109 | conflict |
| Ala 239 | Lys 265 | conflict |
| Asn 367 | - | expression tag |
| Ala 368 | - | expression tag |
| Ala 369 | - | expression tag |
| Glu 370 | - | expression tag |
| Phe 371 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 214469.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1681.1 | |
| All* | Total formula weight | 216493.0 |
