7M6I
Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, BG1-24
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Spike glycoprotein | polymer | 1259 | 139788.0 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2 COVID-19 virus) | S glycoprotein,E2,Peplomer protein |
| 2 | H, M | BG1-24 Fab Heavy Chain | polymer | 229 | 24294.2 | 2 | Homo sapiens | ||
| 3 | L, N | BG1-24 Fab Light Chain | polymer | 215 | 23411.9 | 2 | Homo sapiens | ||
| 4 | D, F, I | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 6 | G | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 7 | B, C, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 26 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 1213 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Pro 986 | Lys 986 | engineered mutation |
| Pro 987 | Val 987 | engineered mutation |
| Ser 1214 | - | expression tag |
| Gly 1215 | - | expression tag |
| Arg 1216 | - | expression tag |
| Leu 1217 | - | expression tag |
| Val 1218 | - | expression tag |
| Pro 1219 | - | expression tag |
| Arg 1220 | - | expression tag |
| Gly 1221 | - | expression tag |
| Ser 1222 | - | expression tag |
| Pro 1223 | - | expression tag |
| Gly 1224 | - | expression tag |
| Ser 1225 | - | expression tag |
| Gly 1226 | - | expression tag |
| Tyr 1227 | - | expression tag |
| Ile 1228 | - | expression tag |
| Pro 1229 | - | expression tag |
| Glu 1230 | - | expression tag |
| Ala 1231 | - | expression tag |
| Pro 1232 | - | expression tag |
| Arg 1233 | - | expression tag |
| Asp 1234 | - | expression tag |
| Gly 1235 | - | expression tag |
| Gln 1236 | - | expression tag |
| Ala 1237 | - | expression tag |
| Tyr 1238 | - | expression tag |
| Val 1239 | - | expression tag |
| Arg 1240 | - | expression tag |
| Lys 1241 | - | expression tag |
| Asp 1242 | - | expression tag |
| Gly 1243 | - | expression tag |
| Glu 1244 | - | expression tag |
| Trp 1245 | - | expression tag |
| Val 1246 | - | expression tag |
| Leu 1247 | - | expression tag |
| Leu 1248 | - | expression tag |
| Ser 1249 | - | expression tag |
| Thr 1250 | - | expression tag |
| Phe 1251 | - | expression tag |
| Leu 1252 | - | expression tag |
| Gly 1253 | - | expression tag |
| His 1254 | - | expression tag |
| His 1255 | - | expression tag |
| His 1256 | - | expression tag |
| His 1257 | - | expression tag |
| His 1258 | - | expression tag |
| His 1259 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 514776.2 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2608.4 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 5751.4 | |
| All* | Total formula weight | 523136.0 |
