7M56
Structure of human endothelial nitric oxide synthase heme domain in complex with 7-((3-(3-aminophenethyl)phenoxy)methyl)quinolin-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nitric oxide synthase, endothelial | polymer | 440 | 49345.8 | 2 | UniProt (P29474) Pfam (PF02898) | Homo sapiens (Human) | Constitutive NOS,cNOS,EC-NOS,Endothelial NOS,eNOS,NOS type III,NOSIII |
| 2 | C, M (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, N (A, B) | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 2 | Chemie (H4B) | |||
| 4 | E, F, O (A, B) | 7-({3-[2-(6-aminopyridin-2-yl)ethyl]phenoxy}methyl)quinolin-2-amine | non-polymer | 370.4 | 3 | Chemie (V5G) | |||
| 5 | G, H, P (A, B) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 6 | I, Q (A, B) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 2 | Chemie (BTB) | |||
| 7 | J (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 8 | K, L (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 9 | R (B) | GADOLINIUM ATOM | non-polymer | 157.3 | 1 | Chemie (GD) | |||
| 10 | S, T (A, B) | water | water | 18.0 | 581 | Chemie (HOH) |
Sequence modifications
A, B: 41 - 480 (UniProt: P29474)
| PDB | External Database | Details |
|---|---|---|
| Glu 298 | Asp 298 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 98691.5 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3829.3 | |
| All* | Total formula weight | 102520.8 |
