7M32
Dihydropyrimidine Dehydrogenase (DPD) C671A Mutant Soaked with Uracil and NADPH Anaerobically
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dihydropyrimidine dehydrogenase [NADP(+)] | polymer | 1025 | 111571.3 | 4 | UniProt (Q28943) Pfam (PF14691) Pfam (PF07992) Pfam (PF01180) Pfam (PF14697) | Sus scrofa (Pig) | DHPDHase,DPD,Dihydrothymine dehydrogenase,Dihydrouracil dehydrogenase |
| 2 | E, EA, F, FA, G... (A, D, B, C) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 16 | Chemie (SF4) | |||
| 3 | I, IA, R, Z (A, D, B, C) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 4 | Chemie (FAD) | |||
| 4 | AA, J, JA, S (C, A, D, B) | URACIL | non-polymer | 112.1 | 4 | Chemie (URA) | |||
| 5 | BA, K, KA, T (C, A, D, B) | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL | non-polymer | 458.4 | 4 | Chemie (FNR) | |||
| 6 | DA, L (D, A) | ALANINE | non-polymer | 89.1 | 2 | Chemie (ALA) | |||
| 7 | CA, M (D, B) | LEUCINE | non-polymer | 131.2 | 2 | Chemie (LEU) | |||
| 8 | U (C) | PROLINE | non-polymer | 115.1 | 1 | Chemie (PRO) | |||
| 9 | LA, MA, NA, OA (A, B, C, D) | water | water | 18.0 | 2630 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 1025 (UniProt: Q28943)
| PDB | External Database | Details |
|---|---|---|
| Asp 60 | Gly 60 | conflict |
| Ala 671 | Cys 671 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 446285.1 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 11605.9 | |
| All* | Total formula weight | 457891.0 |
