7M31
Dihydropyrimidine Dehydrogenase (DPD) C671S Mutant Soaked with Thymine and NADPH Anaerobically
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dihydropyrimidine dehydrogenase [NADP(+)] | polymer | 1025 | 111587.3 | 4 | UniProt (Q28943) Pfam (PF14691) Pfam (PF07992) Pfam (PF01180) Pfam (PF14697) | Sus scrofa (Pig) | DHPDHase,DPD,Dihydrothymine dehydrogenase,Dihydrouracil dehydrogenase |
| 2 | DA, E, EA, F, FA... (D, A, B, C) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 16 | Chemie (SF4) | |||
| 3 | HA, I, Q, Z (D, A, B, C) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 4 | Chemie (FAD) | |||
| 4 | AA, IA, J, R (C, D, A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 5 | CA, K, KA, T (C, A, D, B) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 4 | Chemie (FMN) PubChem (710) PubChem (23585816) PubChem (8965) PubChem (51435500) PubChem (51435503) PubChem (643976) PubChem (5702760) PubChem (7048779) PubChem (7048781) PubChem (15559251) | |||
| 6 | BA, JA, L, S (C, D, A, B) | THYMINE | non-polymer | 126.1 | 4 | Chemie (TDR) PubChem (1135) | |||
| 7 | U (C) | PROLINE | non-polymer | 115.1 | 1 | Chemie (PRO) PubChem (614) PubChem (8988) PubChem (145742) | |||
| 8 | LA, MA, NA, OA (A, B, C, D) | water | water | 18.0 | 4306 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 1025 (UniProt: Q28943)
| PDB | External Database | Details |
|---|---|---|
| Asp 60 | Gly 60 | conflict |
| Ser 671 | Cys 671 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 446349.1 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 14187.0 | |
| All* | Total formula weight | 460536.1 |
